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      Therapeutic effect of Zeng Ye decoction on primary Sjögren's syndrome via upregulation of aquaporin‑1 and aquaporin‑5 expression levels.

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          Abstract

          The aim of this study was to investigate the curative effect of Zeng Ye decoction on primary Sjögren's syndrome (pSS) and further explore its underlying mechanism involving aquaporin (AQP)‑1 and AQP‑5. The pSS model was established based on the immune induction method, and the saliva flow, submandibular gland index, morphological structures of salivary glands, and AQP‑1 and AQP‑5 protein expression levels in the salivary glands were determined. The saliva flow and the submandibular gland index were significantly reduced in the model group (P<0.01, compared with those in the control group), and significantly increased following interferon (IFN), Zeng Ye decoction extraction (ZYE) and Zeng Ye decoction (ZY) treatment (P<0.01, compared with those of the model group). Submandibular gland atrophy, fibrous tissue hyperplasia and multiple focal lymphocytic infiltration were observed in the model group and were attenuated when subjected to IFN, ZYE and ZY treatment. The AQP‑1 and AQP‑5 expression levels increased following IFN, ZYE and ZY treatment (P<0.01, compared with those of the model group), particularly in the ZYE‑35 group. This result indicated that ZYE had a significant protective effect on pSS via upregulation of the expression levels of AQP‑1 and/or AQP‑5. However, the AQP‑1 expression levels increased and the AQP‑5 expression levels decreased in the model groups compared with those in the control group, which indicated different regulatory pathways of the salivary gland damage on the basis of AQP‑1 and AQP‑5. This study provided a significant reference for the prevention and treatment of pSS.

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          Author and article information

          Journal
          Mol Med Rep
          Molecular medicine reports
          Spandidos Publications
          1791-3004
          1791-2997
          Jul 2014
          : 10
          : 1
          Affiliations
          [1 ] Department of Herbal Medicine, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. China.
          [2 ] Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China.
          [3 ] Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.
          [4 ] Department of Pathology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 101121, P.R. China.
          Article
          10.3892/mmr.2014.2208
          24804857
          44d61a01-ca92-4e15-91d5-5fe3f8967ae9
          History

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