+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      Vasomotor reactivity in middle cerebral artery stenosis.

      Journal of the Neurological Sciences

      physiopathology, Vasomotor System, physiology, Vasodilation, Vasoconstriction, Ultrasonography, Doppler, Transcranial, epidemiology, Stroke, Single-Blind Method, Middle Aged, Male, Magnetic Resonance Angiography, pathology, Infarction, Middle Cerebral Artery, Hypertension, Hypercapnia, Humans, Female, Diabetes Mellitus, Constriction, Pathologic, Comorbidity, analysis, Carbon Dioxide, Breath Tests, ultrasonography, Arterioles, Aged

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Vasomotor reactivity (VMR) represents the autoregulatory capacity of cerebral vessels and its clinical significance has been reported in steno-occlusive diseases of internal carotid artery (ICA). However, it has yet to be studied in intracranial steno-occlusive diseases. Consecutive patients with middle cerebral artery (MCA) stenosis diagnosed by MR angiography were compared with age-matched controls. Patients with ipsilateral ICA stenosis or advanced small vessel disease were excluded. Degree of stenosis was graded as mild (< 50%), moderate (50-90%), or severe (> 90%). VMR was measured by a semi-closed rebreathing method with monitoring of end-expiratory CO₂ level and calculated by percentage change of mean flow velocity of MCA. Fifty-eight MCAs with stenosis among 44 patients were compared with 38 MCAs without stenosis among 19 controls. VMR was reduced in patients with stenosis as compared with controls (41.6% vs 57.1%, p < 0.001). VMR was more reduced in patients with previous stroke compared with those without previous stroke (27.5% vs 53.1%, p < 0.001). Decrement of VMR was well correlated with degree of stenosis (p < 0.001). Multivariate logistic regression analysis adjusting for age, hypertension and diabetes revealed moderate to severe stenosis as an independent determinant of reduced VMR (odds ratio 10.2, 95% CI 3.35-30.96, p < 0.001). TCD measurement of VMR is feasible in MCA stenosis and VMR is reduced in a dose-responsive manner. These pilot results need to be replicated and further clinical significance of VMR in MCA stenosis remains to be determined. Copyright © 2010 Elsevier B.V. All rights reserved.

          Related collections

          Author and article information



          Comment on this article