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      Trastornos del movimiento inducidos por Trazodone y Veralipride: casos clínicos Translated title: Trazodone and Veralapride-induced movement disorders: case reports

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          Abstract

          Comunicamos la aparición de movimientos anormales inducidos por dos fármacos de común uso en el adulto: trazodona y veralipride. El primer paciente desarrolla un parkinsonismo luego de una semana de usar Trazodona: la sintomatología se revierte al cabo de algunas semanas de suspendida la droga. El segundo paciente se presenta con una distonía tardía que comprometió extremidades inferiores, pared abdominal y región oro-mandibular luego de 2 meses de usar Veralipride: la sintomatología desaparece luego de 1 mes de suspendida la droga. Esta comunicación enfatiza la necesidad de mayor reconocimiento de este tipo de reacciones adversas de estos fármacos de común uso en nuestro medio

          Translated abstract

          We report the occurrence of abnormal movements induced by two drugs of common use in middle-aged patients: trazodone and veralipride. The first patient developed a akinetic-rigid syndrome after 1 week of using trazodone; the parkinsonism subsided completely a few weeks after drug withdrawal. The second patient presented with a tardive dystonia involved lower limbs, abdominal wall and face after two months of taking veralipride, the movements also gradually disappeared after stopping veralipride. Our report emphasizes the need for more awareness by clinicians of these secondary effects which can severely affect patients

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          Treatment of insomnia in hospitalized patients.

          To provide recommendations for the short-term management of insomnia in hospitalized patients and review patient assessment, nonpharmacologic treatment modalities, and selection of hypnotic medications. Review articles and primary literature representative of current knowledge regarding the treatment of insomnia were identified by MEDLINE search (1966-January 2001). Search terms included insomnia (sleep initiation and maintenance disorders), benzodiazepines, zaleplon, zolpidem, and trazodone. Literature regarding the management of insomnia in hospitalized patients is limited; therefore, data pertinent to the treatment of ambulatory patients must be extrapolated to the inpatient setting. When evaluating insomnia in hospitalized patients, it seems reasonable to obtain a thorough history and physical examination to identify potential underlying etiologies. Treatment of these underlying etiologies should be considered. When the use of a sedative-hypnotic agent is necessary, medication and dose selection should be based on the pharmacokinetic and adverse effect profiles of each agent. Patent-specific characteristics should also be considered to provide effective treatment while minimizing adverse effects. Nonpharmacologic approaches to the treatment of insomnia should be considered for hospitalized patients. When sedative-hypnotic medications must be administered, the pharmacokinetic profile of intermediate-acting benzodiazepines (e.g., lorazepam, temazepam) makes them good first-line agents. Zaleplon and zolpidem are also attractive hypnotic agents; however, they are typically reserved for second-line therapy due to cost. Trazodone may be an alternative for patients unable to take benzodiazepines.
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            Can trazodone induce parkinsonism?

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              A Hemodialysis Patient with Trazodone-Induced Parkinsonism

              A hemodialysis male patient exhibited depressive symptoms and trazodone was prescribed orally. Although his depressive symptoms disappeared, he gradually presented with parkinsonism. His parkinsonism improved within a week after stopping trazodone. The clinical course strongly suggested that it was induced by trazodone. However, there is no report on antidopaminergic side effects of parkinsonism. This case suggests that antidopaminergic effects leading to parkinsonism need to be considered in patients on hemodialysis that are taking trazodone.
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                Author and article information

                Journal
                rchnp
                Revista chilena de neuro-psiquiatría
                Rev. chil. neuro-psiquiatr.
                Sociedad de Neurología, Psiquiatría y Neurocirugía (Santiago, , Chile )
                0717-9227
                June 2005
                : 43
                : 2
                : 133-136
                Affiliations
                [02] orgnameClínica Las Condes Chile
                [01] orgnameUniversidad de Chile orgdiv1Hospital Clínico orgdiv2Departamento Neurología y Neurocirugía Chile
                Article
                S0717-92272005000200006 S0717-9227(05)04300206
                10.4067/S0717-92272005000200006
                44e0f1ed-8623-49db-a8e9-13c969399ce8

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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                Figures: 0, Tables: 0, Equations: 0, References: 9, Pages: 4
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                SciELO Chile

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                Artículos Originales

                trazodone,veralaprida,distonía tardía,extrapyramidal reactions,tardive dystonia,veralipride,trazodona

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