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      Effects of quercetin on antioxidant potential in the experimental periodontitis development

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          Abstract

          The results of experimental research of antioxidant system are presented in this article. Superoxide dismutase activity, catalase, and ceruloplasmin have been determined on the 7 th and 14 th days of experimental periodontitis development both without correction and with the injection of a water-soluble quercetin drug (corvitin). Hence, there was a decrease in superoxide dismutase activity, intensive increase in catalase activity, and ceruloplasmin maintenance in the blood serum during acute period of inflammatory process. The usage of flavonoid for 7  days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat’s blood plasma with experimental bacterial-immune periodontitis.

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          Most cited references20

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          Flavonoids: antioxidants or signalling molecules?

          Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties, there is an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling pathways. Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration
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            Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease.

            There is a growing realization that natural products such as phytochemicals can be used in diets or as supplements to prevent or treat human disease. The disciplines of epidemiology, pharmacognosy, and molecular biology have provided evidence that certain dietary constituents decrease blood pressure, influence immune and neuronal function, affect the incidence of cancer, and ameliorate the abnormal properties of cancer cells. Molecular studies have uncovered the interesting feature that most phytochemicals have multiple modes of action. This review focuses on the flavonoid phytochemical quercetin and describes the myriad of conditions in which quercetin affects a number of physiological processes. Despite the compelling information available, including a number of animal studies, translation of these findings into human clinical trials has been slow. The status of current clinical research on quercetin is summarized, and direction for further research is suggested. © 2014 International Life Sciences Institute.
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              Association of salivary lipid peroxidation levels, antioxidant enzymes, and chronic periodontitis.

              This study assessed the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione reductase (GR), and catalase (CAT) and free radical damage marker malondialdehyde (MDA) levels in saliva of 30 patients with chronic periodontitis (CP) compared to 30 healthy controls by spectrophotometry. MDA levels were significantly elevated in the CP group, whereas the SOD, CAT, and GR activities were significantly reduced compared to healthy controls. MDA levels demonstrated a significant direct correlation with all periodontal parameters, whereas all antioxidant enzymes studied (SOD, CAT, and GR) showed an inverse correlation. These findings support the idea that oxidative stress has a role in periodontal disease pathogenesis.
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                Author and article information

                Journal
                Interv Med Appl Sci
                Interv Med Appl Sci
                imas
                IMAS
                Interventional Medicine & Applied Science
                Akadémiai Kiadó (Budapest )
                2061-1617
                2061-5094
                26 March 2019
                March 2019
                : 11
                : 1
                : 60-64
                Affiliations
                [1 ]Department of Orthopedic Dentistry, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine , Ternopil, Ukraine
                [2 ]Department of Pathophysiology, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine , Ternopil, Ukraine
                Author notes
                [* ]Corresponding author: Petro Hasiuk, MD; Department of Orthopedic Dentistry, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine, Chehova str., 7, Ternopil 46000, Ukraine; Phone: +380 961 4445444; Fax: +380 352 524183; E-mail: p.gasyuk@ 123456gmail.com
                Article
                10.1556/1646.11.2019.06
                7044571
                44e2c8af-0c0f-430b-bb54-93ed11d36144
                © 2019 The Author(s)

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

                Page count
                Figures: 3, Tables: 2, Equations: 0, References: 22, Pages: 5
                Product
                Funding
                Funding sources: No financial support was received for this study.
                Categories
                Original Paper

                periodontitis,catalase,superoxide dismutase,ceruloplasmin,antioxidant protection,quercetin

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