Localisation vaginale de Mansonella perstans: à propos d’un cas au centre hospitalier universitaire de Bobo-Dioulasso, Burkina Faso  <span class="so-article-trans-title" dir="auto"> Translated title: Vaginal localisation of Mansonella perstans: report of a case at the University Hospital of Bobo-Dioulasso, Burkina Faso </span>

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Abstract

Mansonella perstans est une filaire dont les adultes sont à localisation péritonéale et les microfilaires à localisation sanguine, qui sévit principalement en Amérique Equatoriale et aux bords de rivières, de plages en Afrique tropicale humide. Sa transmission est assurée par la piqûre de culicoïdes. Nous rapportons le cas d’une patiente souffrant de prurit dans un contexte biologique d’hyperéosinophilie au cours d’un dépistage du cancer du col de l’utérus. Une microfilaire de Mansonella perstans a été observée sur son frottis cervico-vaginal mais aussi dans son sang. La patiente a été traitée avec succès par une prise unique combinée de 400 mg d’albendazole et d’ivermectine (150 µg/kg). La localisation cervico-vaginale de Mansonella perstans est atypique et exceptionnelle. Nous proposons une recherche systématique de microfilaires lors de frottis cervico-vaginaux des femmes souhaitant un dépistage du cancer du col de l’utérus au Centre Hospitalier de Bobo-Dioulasso pour déterminer la fréquence réelle de cette localisation atypique.

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Most cited references 21

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A randomized trial of doxycycline for Mansonella perstans infection.

Daouda Traore, Ettie Lipner, Sékou F. Traorè … (2009)

Mansonella perstans infection is common in areas of Africa where Wuchereria bancrofti, a causative agent of lymphatic filariasis, is endemic. M. perstans is refractory to standard antifilarial therapies. The recent discovery of bacterial endosymbionts (e.g., wolbachia) in most filarial species, including M. perstans, provides new therapeutic options for reducing microfilaremia. In an open-label, randomized trial, we recruited subjects with M. perstans microfilaremia, with or without concomitant W. bancrofti infection, from four villages in Mali and randomly assigned them to receive doxycycline, at a dose of 200 mg daily for 6 weeks (106 subjects), or no treatment (110). At 6 months, subjects who were coinfected with W. bancrofti underwent a second random assignment, to treatment with a single dose of albendazole (400 mg) and ivermectin (150 microg per kilogram of body weight) or no treatment. Subjects were monitored daily during the first 6-week study period for adverse events. M. perstans and W. bancrofti microfilarial levels were assessed at 6, 12, and 36 months. At 12 months, 67 of 69 subjects who had received treatment with doxycycline only (97%) had no detectable M. perstans microfilariae per 60 microl of blood, as compared with 10 of 63 subjects who had received no treatment (16%) (relative risk, 6.18; 95% confidence interval, 3.63 to 11.89; P<0.001). At 36 months, M. perstans microfilaremia remained suppressed in 48 of 64 subjects who had received treatment with doxycycline only (75%), a finding that was consistent with a macrofilaricidal effect of doxycycline. Vomiting was more frequent in the doxycycline-treated group than in the untreated group (17% vs. 4%). These results are consistent with previous findings that M. perstans harbors the intracellular endosymbiont, wolbachia, and suggest that doxycycline is an effective therapy for M. perstans infection. (ClinicalTrials.gov number, NCT00340691.) 2009 Massachusetts Medical Society

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Epidemiology of concomitant infections due to Loa loa, Mansonella perstans, and Onchocerca volvulus in rain forest villages of Cameroon.

S Ndindeng, N Tendongfor, S Wanji … (2003)

An epidemiological survey was conducted in 16 remote villages of the rain forest of southern Cameroon to ascertain the prevalence and intensity of three species of filariae: Loa loa, Onchocerca volvulus, and Mansonella perstans. We examined 1458 individuals for blood-dwelling microfilariae and 1255 of these were also for the presence of palpable nodules. All the villages surveyed were found highly endemic for onchocerciasis and mansonellosis with prevalence ranging from 28.44% to 87.17% for O. volvulus and 52.48% to 100% for M. perstans. The intensities of infection were also found high for M. perstans with arithmetic means of microfilaremia ranging from 280.94 to 4947.57 mf/ml. The loiasis prevalence was relatively low with value from 2.22% to 19.23%. Males were found more infected than females for the three species of filariae, and the prevalence and intensities of microfilaremia vary differently in males and females at different ages. The three species of filariae displayed different degrees of association in the inhabitants with a low prevalence of co-occurrence between L. loa/O. volvulus and between L. loa/M. perstans. In contrast, there was a high prevalence of co-occurrence between M. perstans and O. volvulus. The implications of the co-occurrence of the three species of filariae in the populations of these remote villages on the intervention programs based on mass treatment with mectizan are discussed.

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Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities.

Santa Asio, Ambrose W Onapa, Sara Simonsen (2009)

Surveys for Mansonella perstans infection and potentially related clinical manifestations were undertaken in two endemic communities in Mukono and Luwero districts of Uganda where no other human filarial infections are transmitted. A sensitive and accurate counting chamber method was used for quantifying microfilaraemia in 100microl of finger-prick blood. Among 575 and 991 examined individuals aged >or=1 year in the two communities, the overall microfilariae (mf) prevalence was significantly higher in Mukono (76.5%) than in Luwero (57.7%). As early as age 1-4 years, 40.6% and 20.5% of the children were mf-positive. Prevalences increased rapidly with increasing age to reach 89.2% and 81.4% in the 15-19 years age group and then remained high in subsequent age groups. The geometric mean mf intensity among mf-positive individuals was slightly higher in the Mukono community (32.4mf/100microl) than in the Luwero community (29.9mf/100microl), and this parameter increased with age in both communities. No obvious associations were observed between various clinical parameters and M. perstans microfilaraemia in any of the study communities. The observed patterns of microfilaraemia and the lack of obvious visible clinical manifestations suggest that the host's regulatory responses are downregulated in M. perstans infections. [ClinicalTrials.gov identifier: NCT00215280].

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Author and article information

Journal

Journal ID (nlm-ta): Pan Afr Med J

Journal ID (iso-abbrev): Pan Afr Med J

Journal ID (publisher-id): PAMJ

Title: The Pan African Medical Journal

Publisher: The African Field Epidemiology Network

ISSN (Electronic): 1937-8688

Publication date (Electronic): 24 June 2012

Publication date Collection: 2012

Volume: 12

Electronic Location Identifier: 47

Affiliations

[1 ]Service de Parasitologie –Mycologie du Centre Hospitalier Universitaire Sanou Souro, Bobo Dioulasso, Burkina Faso

[2 ]Service de Parasitologie -Mycologie de l’institut supérieur des sciences de la santé, Burkina Faso

[3 ]Service de Dermatologie du Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso

[4 ]Service de Parasitologie et Mycologie, Centre Hospitalier Universitaire Henri Mondor, Créteil, France

[5 ]Laboratoire de Parasitologie-Mycologie, Hôpital Maison Blanche, Reims, France, Université polytechnique de Bobo Dioulasso, Burkina Faso

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[& ]Corresponding author: Sanata Bamba, Service de Parasitologie - Mycologie du Centre Hospitalier Universitaire Sanou Souro, Bobo Dioulasso, Burkina Faso

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Publisher ID: PAMJ-12-47

PMC ID: 3428167

PubMed ID: 22937187

SO-VID: 44ea219d-7e24-431d-afe1-c8d9ba9b50a8

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The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Localisation vaginale de Mansonella perstans: à propos d’un cas au centre hospitalier universitaire de Bobo-Dioulasso, Burkina Faso Translated title: Vaginal localisation of Mansonella perstans: report of a case at the University Hospital of Bobo-Dioulasso, Burkina Faso

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Most cited references 21

A randomized trial of doxycycline for Mansonella perstans infection.

Epidemiology of concomitant infections due to Loa loa, Mansonella perstans, and Onchocerca volvulus in rain forest villages of Cameroon.

Mansonella perstans filariasis in Uganda: patterns of microfilaraemia and clinical manifestations in two endemic communities.

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