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      Auxological and Biochemical Evaluation of Pubertal Suppression with the GnRH Agonist Leuprolide Acetate in Early and Precocious Puberty

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          We studied the auxological effects of treatment with the GnRH agonist leuprolide acetate (Lucrin<sup>®</sup>) at 3.75 mg/ 28 days in 38 children with early or precocious puberty. We present our newly developed scoring system, the Puberty Suppression Score (PSS), in which clinical and biochemical parameters determine whether suppression was effective. Leuprolide acetate suppressed pubertal development in the majority of cases. During treatment there was a significant correlation between the number of times that PSS was >0 and gain in predicted adult height (PAH) compared to initial prediction at the start of treatment. After 6 months of treatment, ineffective suppression measured by PSS was associated with the magnitude of gain in PAH. We conclude that a leuprolide acetate dosage of 3.75 mg every 28 days effectively suppresses puberty. PSS is helpful in monitoring the suppressive capacity of a GnRH agonist. We recommend to start with leuprolide acetate at 3.75 mg/28 days and to increase the injection frequency or dose in case PSS is >0 after 6 months of treatment.

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          Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test

           L Ibáñez (1994)

            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            December 1999
            10 January 2000
            : 51
            : 6
            : 270-276
            aDivision of Endocrinology, University Hospital/Sophia Children’s Hospital, Erasmus University, Rotterdam, and bDepartment of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
            23413 Horm Res 1999;51:270–276
            © 2000 S. Karger AG, Basel

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            Figures: 1, Tables: 5, References: 28, Pages: 7
            Original Paper


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