5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Iron in innate immunity: starve the invaders.

      Current Opinion in Immunology
      Animals, Antimicrobial Cationic Peptides, genetics, immunology, Bacterial Infections, physiopathology, Cation Transport Proteins, Cell Degranulation, Disease Susceptibility, Hepcidins, Humans, Immunity, Innate, Ion Transport, Iron, metabolism, Iron Overload, Malaria, Phagocytosis, Transferrin, Virus Diseases

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders. Some microbes have evolved effective countermeasures that blunt the effect of iron restriction. Recent epidemiologic studies have highlighted the potentiating effect of iron on microbial infections. Laboratory studies have focused on specific immune mechanisms that mediate iron withholding from microbes constitutively and in response to infections. Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections.

          Related collections

          Author and article information

          Comments

          Comment on this article