There is a void of studies concerning occupational health aspects from working with the most advanced forms of information technologies techniques such as are found in some of the world-renowned telecommunication systems development laboratories. However, many of these techniques will later be applied in the regular office environment. We wanted to identify some of the major stressors perceived by advanced telecommunication systems design employees and develop a valid and reliable instrument by which to monitor such stressors. We were also interested in assessing the impact of a controlled prospective stress-reduction program on perceived mental stress and specific psychophysiological parameters. A total of 116 employees were recruited. Sixty-one were offered to participate in one of three stress-reduction training programs (intervention group). The additional 50 functioned as a reference group. After a detailed baseline assessment, including a comprehensive questionnaire and psychophysiological measurements, new assessments were made at the end of the formal training program (+ 3 months) and after an additional 5-month period. Results reveal a significant improvement in the intervention group with regard to circulating levels of the stress-sensitive hormone prolactin as well as an attenuation in mental strain. Cardiovascular risk indicators were also improved. Circulating thrombocytes decreased in the intervention group. Type of stress-reduction programs chosen and intensity of participation did not significantly impact results. Coping style was not affected and no beneficial effects were observed with regard to the psychological characteristics of the work, eg intellectual discretion and control over work processes. The survey instrument is now being used in the continuous improvement of work processes and strategic leadership of occupational health issues. The results suggest that prior psychophysiological stress research, based on low- and medium-skill, rather repetitive kinds of jobs, may not be completely applicable to that of skilled professionals. The results indicate that cutting-edge telecommunication systems design employees suffer from significant amounts of mental strain. In addition, there are limited but measurable benefits from a stress-reduction program. More attention should be directed as to how to design healthy and productive work environments in workplaces using advanced information technologies.