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      A New System for Recording Electroretinographical Potentials in Animals

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          Abstract

          Electroretinography can provide meaningful evidence of oculotoxic changes. We describe a new recording system specially constructed for animal experiments. It meets the standards for electroretinographical investigations and recording systems set up by international committees. The recording apparatus has a resolution of 0.49 µV (amplitude) and 1 ms with a sensitivity range of ± 1 mV full scale and a band-pass of 0.03 to 1,000 Hz. The signals are digitized and processed by a computer. The calibration symbol is faithfully represented as a rectangular impulse with an amplitude of 100 µV and a period of 100 ms. Normal values were calculated for 25-week-old albino Wistar rats. The normal range is defined as the mean ± 2 SD for A and B wave parameters. These normal values can serve as reference values for future studies in oculotoxicity.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1994
          1994
          01 April 2010
          : 208
          : 2
          : 98-104
          Affiliations
          Department of Ophthalmology, University of Kiel, FRG
          Article
          310461 Ophthalmologica 1994;208:98–104
          10.1159/000310461
          8183533
          4530c7c7-dbdf-43dc-8b60-af700562adf9
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 25 September 1993
          : 19 October 1993
          Page count
          Pages: 7
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Oculotoxicity,Electroretinography,Albino rats,Normal values,Computer,Apparatus

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