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Abstract
A series of chiral quaternary ammonium salts derived from commercially available (R)-
or (S)-binaphthol have been designed as new C(2)-symmetric chiral phase transfer catalysts.
In order to realize the flexible design of these phase transfer catalysts, the combinatorial
design approach has been developed. These chiral high-performance organocatalysts
have been successfully applied to the highly practical asymmetric synthesis of various
amino acid derivatives including α-alkyl and α,α-dialkyl-α-amino acids in addition
to alkaloids.