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      Sentinel lymph node (SLN) concept in cervical cancer: Current limitations and unanswered questions.

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          Abstract

          Sentinel lymph node (SLN) biopsy has been increasingly used in the management of early-stages cervical cancer instead of systematic pelvic lymph node dissection (PLND). The aim of this article is to give a critical overview of key aspects related to this concept, such as a necessity for reliable detection of micrometastases (MIC) in SLN and the requirements for SLN pathologic ultrastaging, low accuracy of intraoperative detection of SLN involvement, and still a limited evidence of oncological safety of the replacement of PLND by SLN biopsy only in ≥IB1 tumours due to unknown risk of MIC in non-SLN pelvic lymph nodes in patients with negative SLN, and absence of any prospective evidence.

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          Author and article information

          Journal
          Gynecol. Oncol.
          Gynecologic oncology
          Elsevier BV
          1095-6859
          0090-8258
          January 2019
          : 152
          : 1
          Affiliations
          [1 ] Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic. Electronic address: dc@davidcibula.cz.
          [2 ] Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.
          Article
          S0090-8258(18)31286-1
          10.1016/j.ygyno.2018.10.007
          30318103
          4537fe79-2e90-43ac-b0ed-dbeb1b015d57
          History

          Cervical cancer,Low volume disease,Pathologic evaluation,Sentinel lymph node,Ultrastaging

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