New players in high fat diet-induced obesity: LETM1 and CTMP.

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Abstract

Obesity contributes to insulin resistance and is a risk factor for diabetes. C-terminal modulator protein (CTMP) and leucine zipper/EF-hand-containing transmembrane protein 1 (LETM1) have been reported to influence the phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB) signaling pathway via the modulation of PKB activity, a key player for insulin signaling. However, it remains unclear whether CTMP and LETM1 are associated with PI3K/PKB signaling in mouse models of obesity.

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Author and article information

Journal

Journal ID (iso-abbrev): Metab. Clin. Exp.

Title: Metabolism: clinical and experimental

Publisher: Elsevier BV

ISSN (Electronic): 1532-8600

ISSN (Print): 0026-0495

Publication date (Electronic): Mar 2014

Volume: 63

Issue: 3

Affiliations

[1 ] Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH 45437, USA; Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-131, South Korea.

[2 ] Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Shaanxi, 710032, China.

[3 ] Department of Neurosurgery, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea.

[4 ] Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea.

[5 ] Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-131, South Korea.

[6 ] Department of Pharmacology, Korea University College of Medicine, Seoul 136-701, South Korea. Electronic address: LDHKIM@korea.ac.kr.

[7 ] Metabolic Disease Institute, University of Cincinnati, Cincinnati, OH 45437, USA; Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-131, South Korea. Electronic address: insulin@cnu.ac.kr.

Article

Publisher Item ID: S0026-0495(13)00357-0

DOI: 10.1016/j.metabol.2013.10.012

PubMed ID: 24333006

SO-VID: 453a01b0-bf23-40b1-bcb3-f99f94dec884

History

Keywords: LETM1,Insulin signaling,Obesity,PKB,CTMP

Data availability:

Keywords: LETM1, Insulin signaling, Obesity, PKB, CTMP

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