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      Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.

      Neuroreport
      1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Adenosine, analogs & derivatives, pharmacology, Animals, Callithrix, Dopamine, Female, Male, Motor Activity, physiology, Movement, Parkinson Disease, Secondary, chemically induced, drug therapy, physiopathology, Phenethylamines, Purinergic P1 Receptor Agonists, Purinergic P1 Receptor Antagonists, Purines, Receptor, Adenosine A2A, Receptors, Purinergic P1

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          Abstract

          Both adenosine A1 and A2 receptor populations are located in the striatum and can modify locomotor activity, and they may form a therapeutic target for Parkinson's disease (PD). Administration of the selective adenosine A2A antagonist (E)-1,3-diethyl-8-(3,4-dimethoxystyryl)-7-methyl-3,7-dihydro-1H-pu rine-2,6-dione (KW-6002) to MPTP-treated common marmosets increased locomotor activity. In contrast, administration of the selective A1 receptor antagonist 1,3-dipropyl-8-cyclopentylxantine (DPCPX) had no effect on locomotion. Administration of the adenosine A2A receptor agonist 2-[p-[2-(2-aminoethylamino) carbonylethyl] phenethyl amino]-5'-N-ethylcarboxamidoadenosine (APEC) dose dependently suppressed basal locomotor activity. A minimally effective dose of APEC (0.62 mg/kg, i.p) completely reversed the increase in locomotor activity produced by administration of KW-6002. The adenosine A2A receptor appears to be an important target for the treatment of basal ganglia disorders, particularly PD.

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