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Single Intramuscular-dose Toxicity of Samgihwalryeok-Pharmacopuncture in Sprague-Dawley Rats

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      Abstract

      Objectives:This study was performed to examine the single-dose toxicity of Samgihwalryeok pharmacopuncture.Methods:Forty six-week-old Sprague-Dawley (SD) rats were divided into four groups of 10 rats each; each group was then sub-divided into two smaller groups, one of five males and the other of five females. Group 1 (G1, control) received 1.0 mL of normal saline solution, while group 2 (G2, low-dose group), group 3 (G3, mid-does group, and group 4 (G4, high-dose group) received 0.1, 0.5, and 1.0 mL of Samgihwalryeok pharmacopuncture, respectively.Results:No mortalities or clinical signs were observed in the four groups. Also, no significant changes in body weights were observed among the group, and no significant differences in hematology/biochemistry, necropsy, or histopathology results were noted.Conclusion:The above findings suggest that treatment with Samgihwalryeok pharmacopuncture is relatively safe. Further studies on this subject are needed.

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      Most cited references 19

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            Author and article information

            Affiliations
            [1 ] Department of Acupuncture & Moxibustion Medicine, Wonkwang Gwangju Oriental Medical Hospital, Gwangju, Korea
            [2 ] Department of Meridians & Acupoints, College of Oriental Medicine, Wonkwang University, Iksan, Korea
            Author notes
            * Corresponding Author Ahn Seong-Hun. Department of Meridians & Acupoints, College of Oriental Medicine, Wonkwang University, 344-2 Shinyong-Dong, Iksan, Korea. Tel: +82-63-850-6983 Fax: +82-63-857-6458 E-mail: drpoint@ 123456wku.ac.kr
            Journal
            J Pharmacopuncture
            J Pharmacopuncture
            J Pharmacopunct
            Journal of Pharmacopuncture
            KOREAN PHARMACOPUNCTURE INSTITUTE
            2093-6966
            2234-6856
            June 2014
            : 17
            : 2
            : 46-56
            4331996
            10.3831/KPI.2014.17.016
            Copyright ©2014, KOREAN PHARMACOPUNCTURE INSTITUTE

            This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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