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      Phospholipid-binding activity of human mannan-binding lectin

      Immunology Letters
      Elsevier BV

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          Abstract

          Some C-type lectins possess phospholipid-binding ability, which may be of physiological importance. Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. This property was inhibited by EDTA and by monosaccharides, and exhibited a similar pH dependence to the carbohydrate (mannan)-binding activity of MBL. These findings may be of immunological relevance.

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          Author and article information

          Journal
          Immunology Letters
          Immunology Letters
          Elsevier BV
          01652478
          April 1998
          April 1998
          : 61
          : 2-3
          : 191-195
          Article
          10.1016/S0165-2478(98)00031-5
          9657274
          454df174-0310-4cc0-8f67-601d3a49eb15
          © 1998

          https://www.elsevier.com/tdm/userlicense/1.0/

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