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Abstract
Some C-type lectins possess phospholipid-binding ability, which may be of physiological
importance. Human mannan-binding lectin (MBL) was found to bind specifically to solid-phase
phosphatidylserine (PS), phosphatidylinositol (PI) and phosphatidylcholine (PC), but
not cardiolipin (CL), in a concentration-dependent manner. This property was inhibited
by EDTA and by monosaccharides, and exhibited a similar pH dependence to the carbohydrate
(mannan)-binding activity of MBL. These findings may be of immunological relevance.