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      Enhancement of diethylstilbestrol induced cytotoxicity by bcl-2 antisense oligodeoxynucleotides and a glutathione depletor for prostate cancer.

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          Abstract

          Bcl-2 has been shown to prolong cancer cell survival by blocking apoptosis and have the function of scavenging reactive oxygen species. We assessed the efficacy of a novel strategy that relies on antisense bcl-2 oligodeoxynucleotides as well as a glutathione depletor combined with diethylstilbestrol (DES) for hormone independent prostate cancer.

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          Author and article information

          Journal
          J. Urol.
          The Journal of urology
          Ovid Technologies (Wolters Kluwer Health)
          0022-5347
          0022-5347
          Feb 2003
          : 169
          : 2
          Affiliations
          [1 ] Department of Urology, Keio University School of Medicine, Tokyo, Japan.
          Article
          S0022-5347(05)64003-7
          10.1097/01.ju.0000037786.60544.9e
          12544353
          45736703-eb78-47fb-925d-2f72553400bd
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