Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Mechanisms underlying inflammation in neurodegeneration.

Cell

Animals, Brain, pathology, Humans, Inflammation, drug therapy, immunology, physiopathology, Neurodegenerative Diseases

Read this article at

ScienceOpenPublisherPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Inflammation is associated with many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. In this Review, we discuss inducers, sensors, transducers, and effectors of neuroinflammation that contribute to neuronal dysfunction and death. Although inducers of inflammation may be generated in a disease-specific manner, there is evidence for a remarkable convergence in the mechanisms responsible for the sensing, transduction, and amplification of inflammatory processes that result in the production of neurotoxic mediators. A major unanswered question is whether pharmacological inhibition of inflammation pathways will be able to safely reverse or slow the course of disease. 2010 Elsevier Inc. All rights reserved.

      Related collections

      Author and article information

      Journal
      20303880
      2873093
      10.1016/j.cell.2010.02.016

      Comments

      Comment on this article