For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
30
views
2
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
1 collections
    0
    shares
      642
      similar
       All similar
      Are you tired of sifting through news that doesn't interest you?
      Personalize your Karger newsletter today and get only the news that matters to you!

      Sign up

      • Record: found
      • Abstract: found
      • Article: found

      Effect of Topical Na-Hyaluronan on Hemidesmosome Formation in n-Heptanol-Induced Corneal Injury

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The present study investigated the effect of Na-hyaluronan (Na-HA) on the hemidesmosome morphogenesis in n-heptanol-induced corneal wounds. Central epithelial wounds were induced in the rabbit cornea by applying a 5.5-mm round filter paper, which was soaked in n-heptanol, for 60 s. 1% Na-HA in phosphate-buffered saline (PBS) or PBS alone were topically administered to the wounded cornea 4 times daily for up to 7 days. Epithelial healing rates during the first 2 days were not altered by Na-HA. The number of hemidesmosomes in the basement membrane of the central cornea was significantly increased in both 3- and 7-day groups after treatment with 1% Na-HA. The results suggest that topically applied 1% Na-HA may enhance the formation of hemidesmosomes during the early healing phase in n-heptanol-induced corneal wounds.

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: not found

          The hyaluronate receptor is preferentially expressed on proliferating epithelial cells

          A.M. Alho, C.B. Underhill (1989)
          In the present study, we have examined the distribution of the hyaluronate receptor as well as hyaluronate itself in a variety of adult tissues. The hyaluronate receptor was localized with a monoclonal antibody, termed K-3, while hyaluronate was localized using proteolytic fragments of cartilage proteoglycan. Staining with the K-3 monoclonal antibody revealed that the hyaluronate receptor was present in a variety of epithelia including the skin, cheek, tongue, esophagus, vagina, intestines, oviduct, and bladder. However, it was notably absent from epithelial cells of the cornea and stomach as well as from endothelial cells of blood vessels. When present, the hyaluronate receptor was preferentially located in regions of active cell growth, such as in the basal layers of stratified epithelium and at the base of the crypts of Lieberkuhn in intestinal epithelium. A similar phenomenon was observed in cultured 3T3 cells. Cultures of 3T3 cells that were actively proliferating were found to have greater amounts of the receptor than their nonproliferating counterparts. When the various tissues were examined for hyaluronate, it was found to have a widespread distribution, being present in most of the basement membranes and between the cells in stratified epithelium. Indeed, in many cases, the distribution of hyaluronate closely paralleled that of the hyaluronate receptor. These results suggest that the interaction between hyaluronate and its receptor is involved in cell-to-substratum adhesion.
          Article 0 comments Cited 20 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Visualization of hyaluronic acid in the anterior segment of rabbit and monkey eyes

            E. LÜTJEN-DRECOLL, M Schenholm, E Tamm … (1990)
            Article 0 comments Cited 3 times – based on 0 reviews     Review now
              Bookmark
              All references

              Author and article information

              Journal
              Journal ID (publisher-id): ORE
              Journal ID (nlm-ta): Ophthalmic Res
              Journal ID (doi): 10.1159/issn.0030-3747
              Title: Ophthalmic Research
              Publisher: S. Karger AG
              ISSN (Print): 0030-3747
              ISSN (Electronic): 1423-0259
              Publication date Subscription-year: 1998
              Publication date (Print): April 1998
              Publication date (Electronic): 20 February 1998
              Volume: 30
              Issue: 2
              Pages: 96-100
              Affiliations
              Departments of a Ophthalmology and b Pharmacology, c Division of Cell and Tissue Biology, Medical Research Center, College of Medicine, Ewha Women’s University, and d Department of Pediatrics, Younsei University, Seoul, Korea; e St. Eriks Eye Hospital, Karolinska Institute, Stockholm, Sweden
              Article
              Publisher ID: 55460 Other ID: Ophthalmic Res 1998;30:96–100
              DOI: 10.1159/000055460
              PubMed ID: 9523287
              SO-VID: 45890f1e-ffd0-4120-8131-53d656348a10
              Copyright © © 1998 S. Karger AG, Basel
              License:

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              History
              Page count
              Figures: 2, Tables: 1, References: 31, Pages: 5
              Categories
              Subject: Original Paper

              ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
              Keywords: Na-hyaluronan,Cornea,N-Heptanol,Hemidesmosomes,Rabbit
              Data availability:
              ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
              Keywords: Na-hyaluronan, Cornea, N-Heptanol, Hemidesmosomes, Rabbit

              Comments

              Comment on this article

              scite_

              Similar content642

              See all similar

              Cited by7

              See all cited by

              Most referenced authors21

              See all reference authors