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Abstract

'The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle. These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.

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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Vasily V Ogryzko, R.Louis Schiltz, Valya Russanova … (1996)

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The CBP co-activator is a histone acetyltransferase.

A Bannister, T Kouzarides (1996)

The CBP protein acts as a transcriptional adaptor for many different transcription factors by directly contacting DNA-bound activators. One mechanism by which CBP is thought to stimulate transcription is by recruiting the histone acetyltransferase (HAT) P/CAF to the promoter. Here we show that CBP has intrinsic HAT activity. The HAT domain of CBP is adjacent to the binding site for the transcriptional activator E1A. Although E1A displaces P/CAF from CBP, it does not disrupt the CBP-associated HAT activity. Thus E1A carries HAT activity when complexed with CBP. Targeting CBP-associated HAT activity to specific promoters may therefore be a mechanism by which E1A acts as a transcriptional activator.

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A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

J E Taunton, C. Hassig, S L Schreiber (1996)

Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.

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PubMed ID:: 9311776

DOI:: 10.1038/38664

ScienceOpen disciplines: Chemistry

Keywords: Acetylation,Animals,Chromatin,chemistry,metabolism,physiology,Forecasting,Gene Expression Regulation,Heterochromatin,Histones,Humans,Protein Conformation,Transcription, Genetic

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ScienceOpen disciplines: Chemistry

Keywords: Acetylation, Animals, Chromatin, chemistry, metabolism, physiology, Forecasting, Gene Expression Regulation, Heterochromatin, Histones, Humans, Protein Conformation, Transcription, Genetic

Histone acetylation in chromatin structure and transcription.

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Abstract

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Higher order chromatin architecture

Most cited references 58

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

The CBP co-activator is a histone acetyltransferase.

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

Author and article information

Journal

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