51
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      NADPH oxidase in endothelial cells: impact on atherosclerosis.

      Antioxidants & Redox Signaling
      Animals, Arteriosclerosis, pathology, Cell Membrane, metabolism, Endothelial Cells, enzymology, Endothelin-1, Endothelium, Vascular, cytology, Humans, Lipoproteins, LDL, Membrane Glycoproteins, Models, Biological, NADPH Oxidase, physiology, Oxidative Stress, Oxygen, Protein Isoforms, Structure-Activity Relationship

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          An elevated vascular superoxide anion formation has been implicated in the initiation and progression of hypertension and atherosclerosis. In this review, we would like to discuss the generation of superoxide anions by an NADPH oxidase complex in vascular cells. Special focus is on the induction of endothelial NADPH oxidase by proatherosclerotic stimuli. We propose a proatherosclerotic vicious cycle of increased NADPH oxidase-dependent superoxide anion formation, augmented generation and uptake of oxidatively modified low-density lipoprotein, and further potentiation of oxidative stress by oxidized low-density lipoprotein itself, angiotensin II, and endothelin-1 in endothelial cells. Furthermore, novel homologues of NADPH oxidase subunit gp91(phox) are summarized. Future directions of research for a better understanding of the role of NADPH oxidase in the pathogenesis of atherosclerosis and clinical implications are discussed.

          Related collections

          Author and article information

          Comments

          Comment on this article