Ductus venosus velocity waveforms in appropriate and small for gestational age fetuses.

Abstract

The objective of this study was to evaluate differences in ductus venosus velocity waveforms between appropriate and small for gestational age fetuses by using a new index based on the ratio between systolic and atrial peak velocities. Ductus venosus velocity waveforms were cross-sectionally recorded in 164 appropriate for gestational age fetuses at 16-42 weeks of gestation and in 97 small for gestational age fetuses free from structural and chromosomal abnormalities between 24-36 weeks of gestation. Small for gestational age fetuses were divided according to the Doppler findings in arterial peripheral vessels: group A (n = 33), normal ratio between umbilical artery and middle cerebral artery Pulsatility Indices; group B (n = 41), umbilical artery/middle cerebral artery ratio > 95th centile but presence of end diastolic flow in umbilical artery; group C (n = 23), umbilical artery/middle cerebral artery ratio > 95th centile and absence of end diastolic flow in umbilical artery. Eighteen small for gestational age fetuses (10 from group B and 8 from group C) were also serially studied until delivery due to fetal distress. Ductus venosus velocity waveforms were recorded at the level of its origin from umbilical vein and the ratio between systolic and atrial peak velocities (systolic/atrial ratio) calculated. In appropriate for gestational age fetuses, systolic/atrial ratio values significantly decrease with gestation. No significant differences were found in systolic/atrial ratio between appropriate for gestational age fetuses and group A small for gestational age fetuses while, after correction for gestational age, significantly higher values were found in group B (P < or = 0.01) and group C (P < or = 0.001) fetuses. Among these fetuses, those with systolic/atrial ratio above the 95th confidence interval showed a poorer perinatal outcome. No relationships were found between systolic/atrial ratio and Pulsatility Index values from fetal arterial peripheral vessels, while a positive relationship was found with the percentage reverse flow in inferior vena cava. In fetuses serially followed, the systolic/atrial ratio progressively increased approaching the onset of abnormal fetal heart rate patterns. The systolic/atrial ratio allows the evaluation of ductus venosus hemodynamics in small for gestational age fetuses and this index may be useful in the monitoring of such fetuses.