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      Inhibitors of Mitochondrial Ca ++ Uptake Dissociate Potassium-Induced Tension Responses from Increased 45Ca Retention in Rabbit Aortic Smooth Muscle

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          Effects of antimycin A, oligomycin and KCN on tension responses to high K<sup>+</sup> or NE and on related Ca<sup>++</sup> movements were investigated in rabbit aortic smooth muscle. Selected concentrations of antimycin A(10<sup>–6</sup> g/ml), oligomycin (10<sup>–6</sup> g/ml) and KCN (1 mM) had little effect on the K<sup>+</sup>-induced contractile response even though all three agents abolished the increase in La<sup>+++</sup>-resistant low affinity Ca<sup>++</sup> uptake elicited with high K<sup>+</sup>. Though the mitochondrial inhibitors had varied effects on the NE-induced contractile response, they had no effect on the NE-induced decrease in La<sup>+++</sup>-resistant high affinity Ca<sup>++</sup>. Oxygen consumption of the muscle tissue was decreased by antimycin A or oligomycin. These results suggest that the increase in low affinity Ca<sup>++</sup> retention elicited with high K<sup>+</sup> represents Ca<sup>++</sup> uptake by mitochondria. Thus, the correlation between K<sup>+</sup>-induced uptake of Ca<sup>++</sup> and an increased retention of La<sup>+++</sup>-resistant low affinity Ca<sup>++</sup> after exposure to K<sup>+</sup> are sequential events that can be dissociated by inhibitors of mitochondrial Ca<sup>++</sup> uptake.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 18
          : 1-2
          : 28-35
          Department of Pharmacology, University of Texas Health Science Center at Dallas, Dallas, Tex., USA
          158335 Blood Vessels 1981;18:28–35
          © 1981 S. Karger AG, Basel

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          Pages: 8
          Research Paper


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