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      Inhibitors of Mitochondrial Ca ++ Uptake Dissociate Potassium-Induced Tension Responses from Increased 45Ca Retention in Rabbit Aortic Smooth Muscle

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          Abstract

          Effects of antimycin A, oligomycin and KCN on tension responses to high K<sup>+</sup> or NE and on related Ca<sup>++</sup> movements were investigated in rabbit aortic smooth muscle. Selected concentrations of antimycin A(10<sup>–6</sup> g/ml), oligomycin (10<sup>–6</sup> g/ml) and KCN (1 mM) had little effect on the K<sup>+</sup>-induced contractile response even though all three agents abolished the increase in La<sup>+++</sup>-resistant low affinity Ca<sup>++</sup> uptake elicited with high K<sup>+</sup>. Though the mitochondrial inhibitors had varied effects on the NE-induced contractile response, they had no effect on the NE-induced decrease in La<sup>+++</sup>-resistant high affinity Ca<sup>++</sup>. Oxygen consumption of the muscle tissue was decreased by antimycin A or oligomycin. These results suggest that the increase in low affinity Ca<sup>++</sup> retention elicited with high K<sup>+</sup> represents Ca<sup>++</sup> uptake by mitochondria. Thus, the correlation between K<sup>+</sup>-induced uptake of Ca<sup>++</sup> and an increased retention of La<sup>+++</sup>-resistant low affinity Ca<sup>++</sup> after exposure to K<sup>+</sup> are sequential events that can be dissociated by inhibitors of mitochondrial Ca<sup>++</sup> uptake.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 1-2
          : 28-35
          Affiliations
          Department of Pharmacology, University of Texas Health Science Center at Dallas, Dallas, Tex., USA
          Article
          158335 Blood Vessels 1981;18:28–35
          10.1159/000158335
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

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