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      Association and gene-gene interaction analyses for polymorphic variants in CTLA-4 and FOXP3 genes: role in susceptibility to autoimmune thyroid disease.

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          Abstract

          Polymorphic variants of cytotoxic T-lymphocyte antigen-4 (CTLA-4) and forkhead box protein P3 (FOXP3) genes are implicated in dysregulated immune homeostasis and autoimmune disorders. We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.

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          Author and article information

          Journal
          Endocrine
          Endocrine
          Springer Science and Business Media LLC
          1559-0100
          1355-008X
          June 2019
          : 64
          : 3
          Affiliations
          [1 ] Department of Genetics, Osmania University, Hyderabad, Telangana, India.
          [2 ] Department of Biotechnology and Bioinformatics, University of Hyderabad, Hyderabad, Telangana, India. parimala_narne@yahoo.co.in.
          [3 ] Department of Genetics, Osmania University, Hyderabad, Telangana, India. ishaq_50@rediffmail.com.
          [4 ] Salar-E-Millat, Research Centre for Cellular and Molecular Medicine, Princess Esra Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India. ishaq_50@rediffmail.com.
          Article
          10.1007/s12020-019-01859-3
          10.1007/s12020-019-01859-3
          30771152
          45a47dd3-bf59-42b0-bf81-c09b012d89e0
          History

          Hashimoto’s thyroiditis,Autoimmune thyroid disease,Polymorphism,Graves’ disease,FOXP3,CTLA-4

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