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      Angiotensin-Converting Enzyme Activity as a Prognostic Factor in Acute Renal Failure

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          Abstract

          We evaluated serum angiotensin-converting enzyme (ACE) activity and thyroid function to determine the importance as prognostic factors in acute renal failure (ARF). Among 37 ARF patients, 24 survived (recovered group) and 13 died (lethal group). Both serum thyroxine (T<sub>4</sub>) level and ACE activity were lower in ARF as a whole group (n = 37) than normal control group (n = 27, p <0.01). Both serum T<sub>4</sub> level and ACE activity in lethal group (n = 13) were significantly lower than those of the recovered group (n = 24, p < 0.01). Serum ACE activity but not serum T<sub>4</sub> level was significantly related to the prognosis of ARF (p < 0.02, Mantel-Haenszel analysis). This suggests that lowered serum T<sub>4</sub> levels are not a specific indicator of ARF, but lowered ACE activity is significantly related to the prognosis of the patient in ARF. Serum ACE activity seems to be one of several clinically useful prognostic indicators in ARF.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1991
          1991
          11 December 2008
          : 58
          : 4
          : 443-449
          Affiliations
          aSecond Department of Internal Medicine, Tokyo Medical and Dental University, Japan; bTsuchiura Kyodo General Hospital, Ibaraki, Japan
          Article
          186477 Nephron 1991;58:443–449
          10.1159/000186477
          1656289
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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