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      Suppression of arthritis by an inhibitor of nitric oxide synthase

      research-article
      The Journal of Experimental Medicine
      The Rockefeller University Press

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          Abstract

          Nitric oxide (NO), a toxic radical gas produced during the metabolism of L-arginine by NO synthase (NOS), has been implicated as a mediator of immune and inflammatory responses. A single injection of streptococcal cell wall fragments (SCW) induces the accumulation of inflammatory cells within the synovial tissue and a cell-mediated immune response that leads destructive lesions. We show here that NO production is elevated in the inflamed joints of SCW-treated rats. Administration of NG-monomethyl-L-arginine, an inhibitor of NOS, profoundly reduced the synovial inflammation and tissue damage as measured by an articular index and reflected in the histopathology. These studies implicate the NO pathway in the pathogenesis of an inflammatory arthritis and demonstrate the ability of a NOS inhibitor to modulate the disease.

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          Author and article information

          Journal
          J Exp Med
          The Journal of Experimental Medicine
          The Rockefeller University Press
          0022-1007
          1540-9538
          1 August 1993
          : 178
          : 2
          : 749-754
          Article
          93340654
          10.1084/jem.178.2.749
          2191124
          7688035
          45d01314-2a1a-4182-ba81-d3292e70bcfd
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          Medicine
          Medicine

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