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      Expansion of CD8+ T cells that express low levels of the B cell-specific molecule CD20 in patients with multiple myeloma.

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          Abstract

          An expanded cytotoxic/memory T-cell subpopulation expressing low levels of the B-cell-specific CD20 molecule was found in peripheral blood and bone marrow of patients with multiple myeloma at the time of diagnosis, but returned to normal levels following treatment. CD3+CD20dim cells were also increased in monoclonal gammopathy of unknown significance albeit at lower levels. Lower CD3+CD20dim cell numbers at baseline may be associated with lack of response to treatment and a poor outcome. Because expansion of these T cells may be related to disease status, further studies should investigate their potentially unique function in plasma cell dyscrasias.

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          Author and article information

          Journal
          Br. J. Haematol.
          British journal of haematology
          0007-1048
          0007-1048
          Feb 2003
          : 120
          : 3
          Affiliations
          [1 ] Department of Therapeutics, Alexandra Hospital, Athens, Greece.
          Article
          4087
          12580963
          45e0d4bf-ed84-4501-b124-37a89860c47f
          History

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