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      Acute necrotizing enterocolitis in infancy: a review of 64 cases.

      Pediatrics

      complications, Birth Weight, Colonic Diseases, pathology, Enterocolitis, Pseudomembranous, radiography, therapy, Female, Humans, Ileum, Infant, Newborn, Infant, Newborn, Diseases, Intestinal Diseases, Intestinal Mucosa, Intestines, microbiology, surgery, Jejunum, Male, Necrosis, Peritonitis, Pneumoperitoneum, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Prognosis, Respiratory Distress Syndrome, Newborn

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          Abstract

          Sixty-four cases of necrotizing enterocolitis are reviewed. The diagnosis was based on tissue examination in 57 and on the clinical syndrome, including pneumatosis, in 7. Three factors are important in the development of the disease: injury to the intestinal mucosa, bacteria, and feedings. The indications for surgical intervention are pneumoperitoneum, signs of peritonitis, and intestinal obstruction. The importance of stress in the etiology of the disease is confirmed by the high incidence of perinatal complications, particularly hypoxia. The mortality was high, but results are improving with the institution of early aggressive treatment.

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          1143976

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