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      Early urinary and plasma biomarkers for experimental diabetic nephropathy.

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          Abstract

          As the prevalence of diabetes rises, its complications such as diabetic nephropathy affect an increaseing number of patients. Consequently, the need for biomarkers in rodent models which reflect the stage and course of diabetic nephropathy is high. This article focuses on Heart-type fatty acid binding protein (H-FABP), osteopontin (OPN), nephrin, and Neutrophil gelatinase-associated lipocalin (NGAL) in urine, and kidney injury molecule (KIM)-1, clusterin, and tissue inhibitior of metalloproteinases (TIMP) 1 in plasma in uni-nephrectomized rats with streptocotozin-induced type 1 diabetes mellitus, a common animal model to explore renal impairment in the setting of diabetes mellitus.

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          Author and article information

          Journal
          Clin. Lab.
          Clinical laboratory
          1433-6510
          1433-6510
          2012
          : 58
          : 7-8
          Affiliations
          [1 ] Center for Cardiovascular Research/Institute of Pharmacology, Charité, Campus Mitte, Berlin, Germany.
          Article
          22997966

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