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      Non-invasive through-skull brain vascular imaging and small tumor diagnosis based on NIR-II emissive lanthanide nanoprobes beyond 1500 nm.

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          Abstract

          Optical bioimaging by using the new short-wavelength infrared window (SWIR, also named as NIR-II, 1000-1700 nm) is emerged as a next generation imaging technique for disease diagnosis owing to the unprecedented improvements in imaging sensitivity and spatial resolution. However, it is challenging to search new imaging agents with highly biocompatible and bright narrow-band emission located in the 1500-1700 nm (referred as NIR-IIb) region. Here we developed high quality polyacrylic acid (PAA) modified NaYF4:Gd/Yb/Er nanorods (PAA-NRs) with remarkably enhanced NIR-IIb emission and decent bio-compatibility for in vivo cerebral vascular bioimaging and small tumor visualization. These PAA-NRs present efficient narrow-band NIR-IIb emission centered at 1520 with 182 nm of band-width. Owing to the highly efficient NIR-IIb emission, NIR-IIb imaging-guided small tumor (4 mm in diameter) detection is achieved. More importantly, non-invasive optical brain vessel bioimaging with high spatial (∼43.65 μm) and temporal resolution through scalp and skull is obtained without craniotomy. These findings open up the opportunity of designing non-invasive approach for visualization the brain vasculature and tumor in biomedical application.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          Elsevier BV
          1878-5905
          0142-9612
          Jul 2018
          : 171
          Affiliations
          [1 ] College of Physics and Information Science and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, China.
          [2 ] College of Physics and Information Science and Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University, Changsha, Hunan 410081, China. Electronic address: songjunz@hunnu.edu.cn.
          [3 ] Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address: jh.hao@polyu.edu.hk.
          Article
          S0142-9612(18)30291-6
          10.1016/j.biomaterials.2018.04.037
          29689412
          45e6f98b-d98d-477b-af3c-695e28451cf2
          History

          Tumor detection,Short-wavelength infrared window,Rare-earth doped nanophosphors,Dynamic contrast imaging,Vascular optical imaging

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