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      Expression and clinical significance of MAGE and NY-ESO-1 Cancer-Testis Antigens in Adenoid Cystic Carcinoma of the Head and Neck

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          Abstract

          Background

          Adenoid cystic carcinoma of the head and neck (ACC) is a rare but highly malignant tumor. Cancer testis antigens (CTA) represent an immunogenic family of cancer-specific proteins and thus represent an attractive target for immunotherapy.

          Methods

          Eighty-four cases of ACC were identified, the CTAs pan-MAGE (M3H67) and NY-ESO-1 (E978) were detected immunohistochemically and correlated with clinical data.

          Results

          Expression of NY-ESO-1 was found in 48/84 (57.1%) and of pan-MAGE in 28/84 (31.2%). Median OS in NY-ESO-1 positive vs. negative patients was 130.8 and 282.0 months (p=0.223), respectively. OS in pan-MAGE positive vs. negative patients was 105.3 and 190.5 months, respectively (p=0.096). Patients expressing both, NY-ESO-1 and pan-MAGE simultaneously had significantly reduced OS with a median of 90.5 months compared to 282.0 months in negative patients (p=0.047).

          Conclusions

          A significant fraction of ACC patients show expression of the cancer testis antigens NY-ESO-1 and/or Pan-MAGE with promising immunotherapeutic implications.

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          Author and article information

          Journal
          8902541
          3967
          Head Neck
          Head Neck
          Head & neck
          1043-3074
          1097-0347
          18 May 2017
          13 February 2016
          July 2016
          15 August 2017
          : 38
          : 7
          : 1008-1016
          Affiliations
          [1 ]University Medical Center Ulm, Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Ulm, Germany
          [2 ]Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Boston, USA
          [3 ]Department of Ear, Nose and Throat Surgery, Kensington Hospital, Whangarei, NZ
          [4 ]University of Pittsburgh, Hillman Cancer Center, Department of Pathology, Pittsburgh (PA), USA
          [5 ]Department of Otorhinolaryngology, University of Cologne, Germany
          [6 ]Institute of Pathology, University of Cologne, Germany
          [7 ]Ludwig Institute for Cancer Research and Memorial Sloan Kettering Cancer Center, New York (NY), USA
          [8 ]Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York (NY), USA
          [9 ]Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA
          Author notes
          Corresponding author: Simon Laban, MD, University Medical Center Ulm, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Frauensteige 12, 89070 Ulm, Germany, simon.laban@ 123456gmail.com , Phone +49 731 500 59548, Fax +49 731 500 59502
          Article
          PMC5557286 PMC5557286 5557286 nihpa876105
          10.1002/hed.24403
          5557286
          26874246
          45fcd9e9-f159-4e43-8a53-b3c76b6db6d2
          History
          Categories
          Article

          cancer-testis antigens,adenoid cystic carcinoma,head and neck cancer,MAGE,NY-ESO-1

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