7
views
0
recommends
+1 Recommend
2 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      COVID‐19 vaccination in children and university students

      research-article
      1 , 2 ,
      European Journal of Clinical Investigation
      John Wiley and Sons Inc.
      children, COVID‐19, university students, vaccination

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Strategies for the use of COVID‐19 vaccines in children and young adults (in particular university students) are hotly debated and important to optimize. As of late August 2021, recommendations on the use of these vaccines in children vary across different countries. Recommendations are more uniform for vaccines in young adults, but vaccination uptake in this age group shows a large range across countries. Mandates for vaccination of university students are a particularly debated topic with many campuses endorsing mandates in the USA in contrast to European countries, at least as of August 2021. The commentary discusses the potential indirect impact of vaccination of youth on the COVID‐19 burden of disease for other age groups and societal functioning at large, estimates of direct impact on reducing fatalities and nonlethal COVID‐19‐related events in youth, estimates of potential lethal and nonlethal adverse events from vaccines and differential considerations that may exist in the USA, European countries and nonhigh‐income countries. Decision‐making for deploying COVID‐19 vaccines in young people is subject to residual uncertainty on the future course of the pandemic and potential evolution towards endemicity. Rational recommendations would also benefit from better understanding of the clinical and sociodemographic features of COVID‐19 risk in young populations and from dissecting the role of re‐infections and durability of natural vs. vaccine‐induced immunity.

          Related collections

          Most cited references29

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          OpenSAFELY: factors associated with COVID-19 death in 17 million patients

          COVID-19 has rapidly impacted on mortality worldwide. 1 There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major primary care electronic health records vendor. Primary care records of 17,278,392 adults were pseudonymously linked to 10,926 COVID-19 related deaths. COVID-19 related death was associated with: being male (hazard ratio 1.59, 95%CI 1.53-1.65); older age and deprivation (both with a strong gradient); diabetes; severe asthma; and various other medical conditions. Compared to people with white ethnicity, black and South Asian people were at higher risk even after adjustment for other factors (HR 1.48, 1.29-1.69 and 1.45, 1.32-1.58 respectively). We have quantified a range of clinical risk factors for COVID-19 related death in the largest cohort study conducted by any country to date. OpenSAFELY is rapidly adding further patients’ records; we will update and extend results regularly.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

            We report findings in five patients who presented with venous thrombosis and thrombocytopenia 7 to 10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against coronavirus disease 2019 (Covid-19). The patients were health care workers who were 32 to 54 years of age. All the patients had high levels of antibodies to platelet factor 4–polyanion complexes; however, they had had no previous exposure to heparin. Because the five cases occurred in a population of more than 130,000 vaccinated persons, we propose that they represent a rare vaccine-related variant of spontaneous heparin-induced thrombocytopenia that we refer to as vaccine-induced immune thrombotic thrombocytopenia.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

              Estimates of influenza-associated mortality are important for national and international decision making on public health priorities. Previous estimates of 250 000-500 000 annual influenza deaths are outdated. We updated the estimated number of global annual influenza-associated respiratory deaths using country-specific influenza-associated excess respiratory mortality estimates from 1999-2015.
                Bookmark

                Author and article information

                Contributors
                jioannid@stanford.edu
                Journal
                Eur J Clin Invest
                Eur J Clin Invest
                10.1111/(ISSN)1365-2362
                ECI
                European Journal of Clinical Investigation
                John Wiley and Sons Inc. (Hoboken )
                0014-2972
                1365-2362
                26 September 2021
                November 2021
                26 September 2021
                : 51
                : 11 ( doiID: 10.1111/eci.v51.11 )
                : e13678
                Affiliations
                [ 1 ] Departments of Medicine, Epidemiology and Population Health Biomedical Data Science, and Statistics Stanford University Stanford CA USA
                [ 2 ] Meta‐Research Innovation Center at Stanford (METRICS) Stanford University Stanford CA USA
                Author notes
                [*] [* ] Correspondence

                John P. A. Ioannidis, Stanford Prevention Research Center, MSOB X306, 1265 Welch Road, Stanford, CA 94305, USA.

                Email: jioannid@ 123456stanford.edu

                Author information
                https://orcid.org/0000-0003-3118-6859
                Article
                ECI13678
                10.1111/eci.13678
                8646734
                34529274
                4600d642-97e9-4920-afad-6a5a2d87cb28
                © 2021 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 01 September 2021
                : 25 August 2021
                : 06 September 2021
                Page count
                Figures: 0, Tables: 2, Pages: 8, Words: 4887
                Categories
                Commentary
                Commentary
                Custom metadata
                2.0
                November 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.9 mode:remove_FC converted:06.12.2021

                Medicine
                children,covid‐19,university students,vaccination
                Medicine
                children, covid‐19, university students, vaccination

                Comments

                Comment on this article