2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Effects of a Sustained-Release Form of Isosorbide Dinitrate on Left Atrial Pressure in Dogs with Experimentally Induced Mitral Valve Regurgitation

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references22

          • Record: found
          • Abstract: found
          • Article: not found

          Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study.

          To evaluate the effects of vasodilator therapy on mortality among patients with chronic congestive heart failure, we randomly assigned 642 men with impaired cardiac function and reduced exercise tolerance who were taking digoxin and a diuretic to receive additional double-blind treatment with placebo, prazosin (20 mg per day), or the combination of hydralazine (300 mg per day) and isosorbide dinitrate (160 mg per day). Follow-up averaged 2.3 years (range, 6 months to 5.7 years). Mortality over the entire follow-up period was lower in the group that received hydralazine and isosorbide dinitrate than in the placebo group. This difference was of borderline statistical significance. For mortality by two years, a major end point specified in the protocol, the risk reduction among patients treated with both hydralazine and isosorbide dinitrate was 34 percent (P less than 0.028). The cumulative mortality rates at two years were 25.6 percent in the hydralazine--isosorbide dinitrate group and 34.3 percent in the placebo group; at three years, the mortality rate was 36.2 percent versus 46.9 percent. The mortality-risk reduction in the group treated with hydralazine and isosorbide dinitrate was 36 percent by three years. The mortality in the prazosin group was similar to that in the placebo group. Left ventricular ejection fraction (measured sequentially) rose significantly at eight weeks and at one year in the group treated with hydralazine and isosorbide dinitrate but not in the placebo or prazosin groups. Our data suggest that the addition of hydralazine and isosorbide dinitrate to the therapeutic regimen of digoxin and diuretics in patients with chronic congestive heart failure can have a favorable effect on left ventricular function and mortality.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The effect of pimobendan on left atrial pressure in dogs with mitral valve regurgitation.

            The effects of pimobendan on left atrial pressure (LAP) in dogs with mitral valve disease (MR) have not been documented in a quantitative manner.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Estimation of left ventricular filling pressure by use of Doppler echocardiography in healthy anesthetized dogs subjected to acute volume loading.

              To identify Doppler echocardiographic (DE) variables that correlate with left ventricular filling pressure (LVFP).
                Bookmark

                Author and article information

                Journal
                Journal of Veterinary Internal Medicine
                J Vet Intern Med
                Wiley
                08916640
                November 2013
                November 2013
                September 06 2013
                : 27
                : 6
                : 1421-1426
                Affiliations
                [1 ]Department of Veterinary Surgery; Faculty of Veterinary Medicine; Tokyo University of Agriculture and Technology; Tokyo Japan
                Article
                10.1111/jvim.12184
                460526f7-b38b-42d2-921b-11cfbdc9a1a5
                © 2013

                http://doi.wiley.com/10.1002/tdm_license_1.1

                History

                Comments

                Comment on this article