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      The sufficiency of the HAM-D6 as an outcome instrument in the acute therapy of antidepressants in the outpatient setting.

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          Abstract

          Objective. To re-analyse the Spanish outpatient study on the various versions of the Hamilton Depression Scale (HAM-D) by using item-response theory models for measuring unidimensionality. Methods. The Mokken analysis, based on the coefficient of homogeneity, was used. A coefficient of 0.40 or higher was accepted for unidimensionality. The three HAM-D versions were compared: HAM-D6 (core items of depression), HAM-D17 and HAM-D21. Results. In total, 113 of the 116 patients included in the study completed the planned treatment period of 6 weeks. As the Mokken analysis depends as much on the sample of patients under examination (dispersion of scores on the item) as on the scale itself, the endpoint was used. For HAM-D6, but not for HAM-D17 or HAM-D21, the coefficient of homogeneity was acceptable (0.44). Conclusion. The HAM-D6 is a valid version of the Hamilton Scale to be recommended for monitoring depressed patients in antidepressant therapy in the outpatient setting.

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          Author and article information

          Journal
          Int J Psychiatry Clin Pract
          International journal of psychiatry in clinical practice
          Informa UK Limited
          1365-1501
          1365-1501
          2007
          : 11
          : 2
          Affiliations
          [1 ] Area de Psiquiatria, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.
          Article
          10.1080/13651500600971646
          24937560
          4614ae2c-fe43-4798-85df-53d3f45f4d2f
          History

          outpatients,Hamilton Depression Rating Scale-6 (HAM-D6),acute treatment,depression,outcomes,psychometric properties

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