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      Neuropsychiatric Disease and Treatment (submit here)

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      Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff’s syndrome, patients with Parkinson’s disease, and patients with rupture and repair of the anterior communicating artery

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          Abstract

          This study compared patterns of frontal-lobe dysfunction in alcoholics with Korsakoff’s syndrome (KS: n = 9), non-Korsakoff alcoholics (AL: n = 28), patients with Parkinson’s disease (PD: n = 18), and patients with rupture and repair of the anterior communicating artery (ACoA: n = 4) relative to healthy non-neurological control (NC) participants (n = 70). The tests administered were sensitive to functions of dorsolateral prefrontal and orbito-frontal subsystems. Measures included perseverative errors on the Wisconsin Card Sorting Test (WCST-pe), errors on object alternation (OA), errors on Trails B, number of words generated on the Controlled Oral Word Association Test (COWAT), and number of categories completed on the WCST (WCST-cc). KS patients were as impaired as AL participants on orbitofrontal measures and, on dorsolateral prefrontal measures, were impaired relative to AL participants, whose performance did not differ from controls. Patients with PD also were impaired on tests of orbitofrontal and dorsolateral prefrontal functioning but to a lesser extent than the KS patients. Moreover, most of the PD deficits were driven by the impaired performance of patients whose initial symptoms were on the right side of the body. The ACoA patients were significantly impaired on tests of orbitofrontal but not dorsolateral prefrontal functioning relative to the control group. Together, the results confirm different patterns of frontal-system impairments in patient groups having compromised frontal lobe functioning consequent to varying etiologies.

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          Most cited references75

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          Parkinsonism: onset, progression, and mortality

          M Hoehn, M Yahr (1967)
          Neurology, 17(5), 427-427
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            VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE

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              A rating scale for depression.

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                Author and article information

                Journal
                Neuropsychiatr Dis Treat
                Neuropsychiatric Disease and Treatment
                Neuropsychiatric Disease and Treatment
                Dove Medical Press
                1176-6328
                1178-2021
                September 2006
                : 2
                : 3
                : 327-339
                Affiliations
                [1 ] Boston University, Department of Psychology
                [2 ] Boston University School of Medicine, Departments of Anatomy and Neurobiology, Psychiatry, and Neurology
                [3 ] Boston VA Healthcare System, Boston, MA, USA
                Author notes
                Correspondence: Courtney L Dirksen, Lutheran General Children’s Hospital, 1675 Dempster- Y2 108, Park Ridge, IL 60068, USA, Tel +1 847 7236181, Email courtney.dirksen@ 123456gmail.com
                Article
                ndt-2-327
                2671822
                19412479
                461abd45-12bf-4f81-8f7b-28d8634f20f2
                © 2006 Dove Medical Press Limited. All rights reserved
                Categories
                Original Research

                Neurology
                Neurology

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