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      Urinary Excretion of β 2 Microglobulin after the Induction of a Diuresis

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      Nephron

      S. Karger AG

      β2-Microglobulin, Diuresis, Tubular function

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          Abstract

          An increased diuresis was induced in each of four healthy subjects by intravenous infusion of urea, saline and sodium bicarbonate and by an oral water load. The excretion of a low molecular weight protein (LMW-protein), β<sub>2</sub>-Microglobulin (β<sub>2 </sub>µ), was determined by a radioimmunoassay, the urinary concentrations of the protein being in the range 0.007–0,3 µg/ml. The hourly excretion of β<sub>2</sub> µ was not significantly influenced by varying loads of water, sodium, and osmoles which suggests that the tubular reabsorption of LMW-proteins is stable under these conditions and that even a moderately increased excretion of such proteins may reflect a disturbed proximal tubular function.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1976
          1976
          28 November 2008
          : 17
          : 5
          : 343-352
          Affiliations
          Section of Nephrology, Medical Clinic, University Hospital, and Institute of Medical Chemistry, University of Uppsala, Uppsala
          Article
          180740 Nephron 1976;17:343–352
          10.1159/000180740
          61564
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Tubular function, Diuresis, &beta;2-Microglobulin

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