Long-term storage of episodic memories is hypothesized to result from the off-line
transfer of information from the hippocampus to neocortex, allowing a hippocampal-independent
cortical representation to emerge. However, off-line hippocampal-cortical interactions
have not been demonstrated to be linked with long-term memory. Here, using functional
magnetic resonance imaging, we examined if hippocampal-cortical BOLD correlations
during rest following an associative encoding task are related to later associative
memory performance. Our data show enhanced functional connectivity between the hippocampus
and a portion of the lateral occipital complex (LO) during rest following a task with
high subsequent memory compared to pretask baseline resting connectivity. This effect
is not seen during rest following a task with poor subsequent memory. Furthermore,
the magnitude of hippocampal-LO correlations during posttask rest predicts individual
differences in later associative memory. These results demonstrate the importance
of postexperience resting brain correlations for memory for recent experiences.
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