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      Cohesin: its roles and mechanisms.

      1 ,
      Annual review of genetics
      Annual Reviews

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          Abstract

          The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

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          Author and article information

          Journal
          Annu Rev Genet
          Annual review of genetics
          Annual Reviews
          1545-2948
          0066-4197
          2009
          : 43
          Affiliations
          [1 ] Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. kim.nasmyth@bioch.ox.ac.uk
          Article
          10.1146/annurev-genet-102108-134233
          19886810
          463e8399-2fa2-445d-8114-d125674bd89d
          History

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