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      Cohesin: its roles and mechanisms.

      Annual review of genetics

      Animals, Cell Cycle Proteins, metabolism, Chromosomal Proteins, Non-Histone, Chromosomes, DNA, Humans, Models, Biological

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          Abstract

          The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

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          Journal
          19886810
          10.1146/annurev-genet-102108-134233

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