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      Glomerular Nonmuscle-Type Myosin Heavy-Chain Isoform Gene Expression in Glomerulosclerosis


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          This study was designed to assess how the glomerular expression of the nonmuscle-type myosin heavy-chain isoform, SMemb, is regulated in rats with focal glomerulosclerosis induced by puromycin aminonucleoside. SMemb was barely detectable in control glomeruli. On day 48 of focal glomerulosclerosis, SMemb was expressed in mesangial area and glomerular epithelial cells. When glomerulosclerosis became prominent on day 80, SMemb stained immunohistochemically in a focal segmental pattern in the sclerotic glomeruli. SMemb-expressing cells did not always express α-smooth muscle actin. In Northern blot analysis, SMemb mRNA was not detected in control glomeruli, whereas it was transiently upregulated in glomeruli on day 48 in rats with focal glomerulosclerosis. The mRNA levels of SMemb were thereafter gradually downregulated by day 80; however, they remained higher than those of control glomeruli. These data suggest that glomerular embryonic nonmuscle-type myosin heavy chain is abnormally regulated in glomerulosclerosis and that glomerulosclerosis may be associated with dedifferentiation of not only the mesangial cells, but also the other resident glomerular cells.

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          Author and article information

          S. Karger AG
          July 1998
          22 June 1998
          : 79
          : 3
          : 317-321
          Division of Nephrology, Department of Medicine, Koto Hospital, Tokyo,Department of Medicine, Juntendo University School of Medicine, Tokyo,2nd and 3rd Departments of Medicine, University of Tokyo, Japan
          45056 Nephron 1998;79:317–321
          © 1998 S. Karger AG, Basel

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          Page count
          Pages: 5
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45056
          Self URI (text/html): https://www.karger.com/Article/FullText/45056
          Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
          Original Paper

          Cardiovascular Medicine,Nephrology
          Mesangial cells,Nonmuscle-type myosin heavy-chain isoform,Glomerulosclerosis


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