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      Review: Sex and the human placenta: mediating differential strategies of fetal growth and survival.

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      Placenta
      Elsevier BV

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          Abstract

          There are known sex specific differences in fetal and neonatal morbidity and mortality. There are also known differences in birthweight centile with males generally being larger than females at birth. These differences are generally ignored when studying obstetric complications of pregnancy and the mechanisms that confer these differences between the sexes are unknown. Current evidence suggests sex specific adaptation of the placenta may be central to the differences in fetal growth and survival. Our research examining pregnancies complicated by asthma has reported sexually dimorphic differences in fetal growth and survival with males adapting placental function to allow for continued growth in an adverse maternal environment while females reduce growth in an attempt to survive further maternal insults. We have reported sex differences in placental cytokine expression, insulin-like growth factor pathways and the placental response to cortisol in relation to the complication of asthma during pregnancy. More recently we have identified sex specific alterations in placental function in pregnancies complicated by preterm delivery which were associated with neonatal outcome and survival. We propose the sexually dimorphic differences in growth and survival of the fetus are mediated by the sex specific function of the human placenta. This review will present evidence supporting this hypothesis and will argue that to ignore the sex of the placenta is no longer sound scientific practice.

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          Author and article information

          Journal
          Placenta
          Placenta
          Elsevier BV
          1532-3102
          0143-4004
          Mar 2010
          : 31 Suppl
          Affiliations
          [1 ] Robinson Institute, Department of Paediatrics and Reproductive Health, Faculty of Health Sciences, Medical North, Level 6, Frome Road, University of Adelaide, Adelaide, SA 5005, Australia. Vicki.clifton@adelaide.edu.au
          Article
          S0143-4004(09)00373-7
          10.1016/j.placenta.2009.11.010
          20004469
          466ea643-5bef-48e6-8046-6789c572c323
          Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.
          History

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