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      The Mechanisms and Applications of Quorum Sensing (QS) and Quorum Quenching (QQ)

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          Abstract

          Quorum sensing (QS) is a regulatory system that regulates the behavior of microbial populations by sensing the concentration of signal molecules that are spontaneously produced and released by bacteria. The strategy of blocking the QS system and inhibiting the production of virulence factors is termed as quorum quenching (QQ). This strategy attenuates virulence without killing the pathogens, thereby weakening the selective pressure on pathogens and postponing the evolution of QQ-mediated drug resistance. In recent years, there have been significant theoretical and practical developments in the field of QS and QQ. In particular, with the development and utilization of marine resources, more and more marine microbial species have been found to be regulated by these two mechanisms, further promoting the research progress of QS and QQ. In this review, we described the diversity of QS signals and QS-related regulatory systems, and then introduced mechanisms related to QS interference, with particular emphasis on the description of natural QQ enzymes and chemicals acting as QS inhibitors. Finally, the exploitation of quorum sensing quenchers and the practical application of QQ were introduced, while some QQ strategies were proposed as promising tools in different fields such as medicine, aquaculture, agriculture and biological pollution prevention areas.

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          Author and article information

          Journal
          JOUC
          Journal of Ocean University of China
          Science Press and Springer (China )
          1672-5182
          12 November 2019
          01 December 2019
          : 18
          : 6
          : 1427-1442
          Affiliations
          1College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
          2Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
          3Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
          Author notes
          *Corresponding author: WANG Yan
          Article
          s11802-019-4073-5
          10.1007/s11802-019-4073-5
          Copyright © Ocean University of China, Science Press and Springer-Verlag GmbH Germany 2019.

          The copyright to this article, including any graphic elements therein (e.g. illustrations, charts, moving images), is hereby assigned for good and valuable consideration to the editorial office of Journal of Ocean University of China, Science Press and Springer effective if and when the article is accepted for publication and to the extent assignable if assignability is restricted for by applicable law or regulations (e.g. for U.S. government or crown employees).

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          Self URI (journal-page): https://www.springer.com/journal/11802

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