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      Effect of Ketanserin, a New Inhibitor of 5-HT 2 Receptors, on Plasma Renin Activity and Aldosterone Levels in Normal Subjects

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          The effect of intravenous administration (10 mg) of ketanserin, a pure, specific and selective blocking agent of 5-HT<sub>2</sub> receptors (R 41 468: 3-{2-[4-(4-fluorobenzoyl)-1-piper-idinyl]ethyl}-2,4(1H,3H)-quinazolinedione) on the renin-angiotensin-aldosterone system and blood pressure in 5 normal male volunteers was compared to the effect of saline alone. Ketanserin induced a small increase in plasma levels of both renin activity and aldosterone, which was not significantly different from that observed during control test. There was no significant effect on systolic and diastolic blood pressure. These preliminary data suggest that 5-HT<sub>2</sub> receptors are probably not involved in the physiological control of basal renin secretion. However, further investigations are needed to elucidate the effects of ketanserin on the renin secretion and blood pressure.

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          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 16
          : 4
          : 244-248
          Institute of Clinical Medicine, University of Ferrara, Ferrara, Italy
          179508 Horm Res 1982;16:244–248
          © 1982 S. Karger AG, Basel

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