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      Effect of Ketanserin, a New Inhibitor of 5-HT 2 Receptors, on Plasma Renin Activity and Aldosterone Levels in Normal Subjects

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          Abstract

          The effect of intravenous administration (10 mg) of ketanserin, a pure, specific and selective blocking agent of 5-HT<sub>2</sub> receptors (R 41 468: 3-{2-[4-(4-fluorobenzoyl)-1-piper-idinyl]ethyl}-2,4(1H,3H)-quinazolinedione) on the renin-angiotensin-aldosterone system and blood pressure in 5 normal male volunteers was compared to the effect of saline alone. Ketanserin induced a small increase in plasma levels of both renin activity and aldosterone, which was not significantly different from that observed during control test. There was no significant effect on systolic and diastolic blood pressure. These preliminary data suggest that 5-HT<sub>2</sub> receptors are probably not involved in the physiological control of basal renin secretion. However, further investigations are needed to elucidate the effects of ketanserin on the renin secretion and blood pressure.

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          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1982
          1982
          25 November 2008
          : 16
          : 4
          : 244-248
          Affiliations
          Institute of Clinical Medicine, University of Ferrara, Ferrara, Italy
          Article
          179508 Horm Res 1982;16:244–248
          10.1159/000179508
          © 1982 S. Karger AG, Basel

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          Pages: 5
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