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Pediatric Cardiology: Advances Over the Past 2 Years and Future Prospects

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      Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.

      Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce.
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        High Frequency of Detection by PCR of Viral Nucleic Acid in The Blood of Infants Presenting with Clinical Myocarditis.

        Specific viruses are associated with pediatric myocarditis, but the prevalence of viral DNAemia detected by blood polymerase chain reaction (PCR) is unknown. We evaluated the prevalence of known cardiotropic viruses (enterovirus, adenovirus, human herpesvirus 6, and parvovirus B19) in children with clinical myocarditis (n = 21). Results were compared to pediatric controls with similar viral PCR testing. The majority of positive PCR (89 %) was noted in children ≤12 months of age at diagnosis compared to older children. Infant myocarditis patients (8/10) had increased the prevalence of PCR positivity compared to infant pediatric controls (4/114) (p < 0.0001). Other than age, patient characteristics at diagnosis were similar between PCR-positive and PCR-negative patients. Both PCR-negative myocarditis infants had clinical recovery at follow-up. Of the PCR-positive myocarditis infants, 4 had clinical recovery, 2 developed chronic cardiomyopathy, 1 underwent heart transplant, and 1 died. Infants with clinical myocarditis have a high rate of blood viral positivity, which is higher compared to older children with myocarditis and healthy infant controls. Age-related differences in PCR positivity may be due to differences in host and/or virus characteristics. Our findings suggest that viral blood PCR may be a useful diagnostic tool and identify patients who would potentially benefit from virus-specific therapy.
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          Erythrocytic hydrogen sulfide production is increased in children with vasovagal syncope.

          To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS).
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            Author and article information

            Affiliations
            Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
            Author notes
            Address for correspondence: Prof. Jun-Bao Du, Department of Pediatrics, Peking University First Hospital, Beijing 100034, China E-Mail: junbaodu1@ 123456126.com
            Journal
            Chin Med J (Engl)
            Chin. Med. J
            CMJ
            Chinese Medical Journal
            Medknow Publications & Media Pvt Ltd (India )
            0366-6999
            05 December 2017
            : 130
            : 23
            : 2776-2777
            29176135 5717854 CMJ-130-2776 10.4103/0366-6999.219153
            Copyright: © 2017 Chinese Medical Journal

            This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

            Categories
            Editorial

            pediatric, cardiology, advances

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