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      Active nematics

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          Abstract

          Active matter extracts energy from its surroundings at the single particle level and transforms it into mechanical work. Examples include cytoskeleton biopolymers and bacterial suspensions. Here, we review experimental, theoretical and numerical studies of active nematics - a type of active system that is characterised by self-driven units with elongated shape. We focus primarily on microtubule–kinesin mixtures and the hydrodynamic theories that describe their properties. An important theme is active turbulence and the associated motile topological defects. We discuss ways in which active turbulence may be controlled, a pre-requisite to harvesting energy from active materials, and we consider the appearance, and possible implications, of active nematics and topological defects to cellular systems and biological processes.

          Abstract

          Active matter systems are made up of self-driven components which extract energy from their surroundings to generate mechanical work. Here the authors review the subfield of active nematics and provide a comparison between theoretical findings and the corresponding experimental realisations.

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          Collective migration of an epithelial monolayer in response to a model wound.

          Using an original microfabrication-based technique, we experimentally study situations in which a virgin surface is presented to a confluent epithelium with no damage made to the cells. Although inspired by wound-healing experiments, the situation is markedly different from classical scratch wounding because it focuses on the influence of the free surface and uncouples it from the other possible contributions such as cell damage and/or permeabilization. Dealing with Madin-Darby canine kidney cells on various surfaces, we found that a sudden release of the available surface is sufficient to trigger collective motility. This migration is independent of the proliferation of the cells that mainly takes place on the fraction of the surface initially covered. We find that this motility is characterized by a duality between collective and individual behaviors. On the one hand, the velocity fields within the monolayer are very long range and involve many cells in a coordinated way. On the other hand, we have identified very active "leader cells" that precede a small cohort and destabilize the border by a fingering instability. The sides of the fingers reveal a pluricellular actin "belt" that may be at the origin of a mechanical signaling between the leader and the followers. Experiments performed with autocrine cells constitutively expressing hepatocyte growth factor (HGF) or in the presence of exogenous HGF show a higher average velocity of the border and no leader.
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            The Mechanics and Statistics of Active Matter

            Active particles contain internal degrees of freedom with the ability to take in and dissipate energy and, in the process, execute systematic movement. Examples include all living organisms and their motile constituents such as molecular motors. This article reviews recent progress in applying the principles of nonequilibrium statistical mechanics and hydrodynamics to form a systematic theory of the behaviour of collections of active particles -- active matter -- with only minimal regard to microscopic details. A unified view of the many kinds of active matter is presented, encompassing not only living systems but inanimate analogues. Theory and experiment are discussed side by side.
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              Hydrodynamic Phenomena in Suspensions of Swimming Microorganisms

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                Author and article information

                Contributors
                amin.doostmohammadi@physics.ox.ac.uk
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                21 August 2018
                21 August 2018
                2018
                : 9
                : 3246
                Affiliations
                [1 ]ISNI 0000 0004 1936 8948, GRID grid.4991.5, The Rudolf Peierls Centre for Theoretical Physics, , University of Oxford, Clarendon Laboratory, ; Parks Rd., Oxford, OX1 3PU UK
                [2 ]ISNI 0000 0004 1937 0247, GRID grid.5841.8, Departament de Ciència de Materials i Química Física and Institute of Nanoscience and Nanotechnology, , Universitat de Barcelona, ; Martí I Franquès 1, 08028 Barcelona, Catalonia Spain
                Author information
                http://orcid.org/0000-0002-1116-4268
                Article
                5666
                10.1038/s41467-018-05666-8
                6104062
                30131558
                468b47b1-a569-4184-9651-3e68d7717a09
                © The Author(s) 2018

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 8 August 2017
                : 28 June 2018
                : 19 July 2018
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