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      Genetic Analysis on the Role of Integrin during Axon Guidance in Drosophila

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          Abstract

          Heterodimeric cell surface receptor integrin is widely expressed in the nervous system, but its specific role during axon development has not been directly tested in vivo. We show that the Drosophila nervous system expresses low levels of positron-specific (PS) integrin subunits αPS1, αPS2, and βPS during embryonic axogenesis. Furthermore, certain subsets of neurons express higher levels of integrin mRNAs than do the rest. Null mutations in either the αPS1 or αPS2 subunit gene cause widespread axon pathfinding errors that can be rescued by supplying the wild-type integrin subunit to the mutant nervous system. In contrast, misexpressing either the αPS1 or αPS2 integrin subunit in all neurons leads to no obvious axon pathfinding errors. We propose that integrin does not itself serve as either a “clutch” constituting molecule or a specific growth cone “receptor,” as proposed previously, but rather as part of a molecular network that cooperatively guarantees accurate axon guidance.

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          Author and article information

          Journal
          J Neurosci
          J. Neurosci
          jneuro
          jneurosci
          J. Neurosci
          The Journal of Neuroscience
          Society for Neuroscience
          0270-6474
          1529-2401
          1 October 1998
          : 18
          : 19
          : 7847-7855
          Affiliations
          [ 1 ]Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801
          Article
          PMC6793012 PMC6793012 6793012 2374
          10.1523/JNEUROSCI.18-19-07847.1998
          6793012
          9742153
          469f491d-a8fa-4113-a46b-3049d4ae63d0
          Copyright © 1998 Society for Neuroscience
          History
          : 21 April 1998
          : 13 July 1998
          : 17 July 1998
          Categories
          Article
          Custom metadata
          5.00

          growth cone,integrin, inflated ,βPS,αPS1, multiple edematous wings , Drosophila , myospheroid ,neuromuscular,pathfinding,αPS2,axon guidance

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