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      Mapping multidimensional pain experience onto electrophysiological responses to noxious laser heat stimuli.

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          Abstract

          The origin of the conscious experience of pain in the brain is a continuing enigma in neuroscience. To shed light on the brain representation of a multifaceted pain experience in humans, we combined multivariate analysis of subjective aspects of pain sensations with detailed, single-trial analysis of electrophysiological brain responses. Participants were asked to fully focus on any painful or non-painful sensations occurring in their left hand during an interval surrounding the onset of noxious laser heat stimuli, and to rate their sensations using a set of visual analogue scales. Statistical parametric mapping was used to compute a multivariate regression analysis of subjective responses and single-trial laser evoked potentials (LEPs) at subject and group levels. Standardized Low Resolution Electromagnetic Tomography method was used to reconstruct sources of LEPs. Factor analysis of subjective responses yielded five factors. Factor 1, representing pain, mapped firstly as a negative potential at the vertex and a positive potential at the fronto-temporal region during the 208-260ms interval, and secondly as a strong negative potential in the right lateral frontal and prefrontal scalp regions during the 1292-1340ms interval. Three other factors, labelled "anticipated pain", "stimulus onset time", and "body sensations", represented non-specific aspects of the pain experience, and explained portions of LEPs in the latency range from 200ms to 700ms. The subjective space of pain during noxious laser stimulation is represented by one large factor featuring pain intensity, and by other factors accounting for non-specific parts of the sensory experience. Pain is encoded in two separate latency components with different scalp and brain representations.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          1095-9572
          1053-8119
          Jan 15 2016
          : 125
          Affiliations
          [1 ] Department of Psychological Sciences, University of Liverpool, Liverpool L69 7ZA, UK. Electronic address: a.stancak@liverpool.ac.uk.
          [2 ] Department of Psychological Sciences, University of Liverpool, Liverpool L69 7ZA, UK.
          Article
          S1053-8119(15)00938-6
          10.1016/j.neuroimage.2015.10.028
          26477652
          46a04f61-e654-4434-950d-47e0c8a9377a
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

          Event-related potentials,Laser evoked potentials,Pain,sLORETA

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