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      Radioimmunoassay of Melatonin: Human Serum and Cerebrospinal Fluid

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          Using a newly characterized anti-melatonin serum it has been possible to establish human serum melatonin concentrations at short time intervals during 24 h. A clear circadian rhythm with peak values during the dark phase was demonstrated in both men and women. Values (pg/ml; mean ± SE) were as follows: females 02.00 h: 130 ± 7, 18.00 h: 45 ± 5; males 02.00 h: 140 ± 11, 18.00 h: 70 ± 5. The estimation (pg/ml; mean ± SE) of melatonin in human serum (males: 63 ± 22 and females: 100 ± 45) and cerebrospinal fluid simultaneously taken has shown that melatonin is lower in cerebrospinal fluid (males: 59 ± 33 and females: 57 ± 28). Blanks are not subtracted.

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          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 8
          : 2
          : 65-75
          Clinique Universitaire de Pédiatrie, Geneva, and Department of Psychiatry, Karolinska Institute, St. Goran’s Hospital, Stockholm
          178782 Horm Res 1977;8:65–75
          © 1977 S. Karger AG, Basel

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          Pages: 11


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