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      Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles

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          Abstract

          The physicochemical properties (solubilization, structural organization and stability) of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP), a promising photosensitizer for photodynamic therapy, solubilized in polymeric micelles of tri-block copolymers PluronicTM P-123 and F-127, were studied. The formulations obtained by the solid dispersion method led to monomerization of TMPP in these copolymers. Solubility studies showed that P-123 solubilizes double the photosensitizer than F-127. The self-aggregation phenomenon was affected by the [TMPP]/[poloxamer] ratio and medium temperature. The decrease in the temperature of these systems promoted the formation of different kinds of TMPP aggregates intrinsically connected with the structural changes occurring in the micelles.

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          Chemical Kinetics and Reactions Mechanisms

          H. Espenson J., J. H. Espenson, JH ESPENSON … (1995)
          Book 0 comments Cited 26 times – based on 0 reviews
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            Identification of radioproducts resulting from the breakage of thymine moiety by gamma irradiation of E. coli DNA in an aerated aqueous solution.

            R Téoule, C. Bert, M Polverelli … (1973)
            Article 0 comments Cited 15 times – based on 0 reviews     Review now
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              Processing of model single-strand breaks in phi X-174 RF transfecting DNA by Escherichia coli.

              Y W Kow, G Faundez, R J Melamede … (1991)
              The inactivation efficiency and repair of single-strand breaks was investigated using model strand breaks created by endonucleolytic incision of damaged DNA. Phi X-174 duplex transfecting DNA containing either thymine glycols, urea residues, or abasic (AP) sites was incubated with AP endonucleases that produce breaks on the 3' side, the 5' side, or both sides of the lesion. For each lesion, incubation with Escherichia coli endonuclease III results in a single-strand break containing a 3' alpha, beta-unsaturated aldehyde (4-hydroxy-2-pentenal), while treatment of AP- or urea-containing DNA with E. coli endonuclease IV results in a single-strand break containing a 5' deoxyribose or a 5' deoxyribosylurea moiety, respectively. Incubation of lesion-containing DNA with both enzymes results in a base gap. Ligatable nicks containing 3' hydroxyl and 5' phosphate moieties were produced by subjecting undamaged DNA to DNase I. When the biological activity of these DNAs was assessed in wild-type cells, ligatable nicks were not lethal, but each of the other strand breaks tested was lethal, having inactivation efficiencies between 0.12 and 0.14. These inactivation efficiencies are similar to those of the base lesions from which the strand breaks were derived. In keeping with the current model of base excision repair, when phi X duplex DNA containing strand breaks with a blocked 3' terminus was transfected into an E. coli double mutant lacking the major 5' cellular AP endonucleases, a greater than twofold decrease in survival was observed. Moreover, when this DNA was treated with a 5' AP endonuclease prior to transfection, the survival returned to that of wild type. As expected, when DNA containing strand breaks with a 5' blocked terminus or DNA containing base gaps was transfected into the double mutant lacking 5' AP endonucleases, the survival was the same as in wild-type cells. The decreased survival of transfecting DNA containing thymine glycols, urea, or AP sites observed in appropriate base excision repair-defective mutants was also obviated if the DNA was incubated with the homologous enzyme prior to transfection. Thus, in every case, with both base lesions and single-strand breaks, the lesion was repaired in the cell by the enzyme that recognizes it in vitro. Furthermore, the repair step in the cell could be eliminated if the appropriate enzyme was added in vitro prior to transfection.(ABSTRACT TRUNCATED AT 400 WORDS)
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                Author and article information

                Contributors
                Bruno H. Vilsinski: Role: ND
                Jader L. Aparicio: Role: ND
                Paulo Cesar de Souza Pereira: Role: ND
                Silvia Luciana Fávaro: Role: ND
                Katieli S. Souza Campanholi: Role: ND
                Adriana P. Gerola: Role: ND
                André L. Tessaro: Role: ND
                Noboru Hioka: Role: ND
                Wilker Caetano: Role: ND
                Journal
                Journal ID (publisher): qn
                Title: Química Nova
                Abbreviated Title: Quím. Nova
                Publisher: Sociedade Brasileira de Química (São Paulo )
                ISSN: 1678-7064
                Publication date (Print): 2014
                Volume: 37
                Issue: 10
                Pages: 1650-1656
                Affiliations
                [1 ] Universidade Estadual de Maringá Brazil
                [2 ] Universidade de Coimbra Portugal
                [3 ] Universidade Tecnológica Federal do Paraná Brazil
                Article
                Publisher ID: S0100-40422014001000014
                DOI: 10.5935/0100-4042.20140273
                SO-VID: 46b04612-6c6a-4c6a-8945-b177def3beb2
                License:

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-4042&lng=en
                Categories
                Subject: CHEMISTRY, MULTIDISCIPLINARY

                ScienceOpen disciplines: General chemistry
                Keywords: meso-tetrakis(p-methoxyphenyl)porphyrin,polymeric micelles,photodynamic therapy
                Data availability:
                ScienceOpen disciplines: General chemistry
                Keywords: meso-tetrakis(p-methoxyphenyl)porphyrin, polymeric micelles, photodynamic therapy

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