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      Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.

      Lancet

      Acute Disease, Adult, Child, Chromosomes, Human, X, Chromosomes, Human, Y, Female, Graft vs Host Disease, therapy, Haploidy, Humans, Immunosuppression, In Situ Hybridization, Fluorescence, Intestinal Mucosa, ultrastructure, Lymphocyte Culture Test, Mixed, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells, immunology, Transplantation Chimera, Transplantation, Homologous

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          Abstract

          Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.

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          Journal
          15121408
          10.1016/S0140-6736(04)16104-7

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