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      Effect of Fasting for Two Days on the Excretion of Ammonium in Dogs with Chronic Metabolic Acidosis

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          Abstract

          Background: The source of glutamine for renal ammonium production is ultimately dietary protein in the fed state and body proteins in fasting. Objective: Our objective was to determine if less NH<sup>+</sup><sub>4</sub> would be excreted by fasted dogs with chronic metabolic acidosis resulting in conservation of lean body mass. Methods: Acid-loaded fed and fasted dogs were given 10 mmol NH<sub>4</sub>Cl/kg for 5 days; the fasted group had food withheld on days 4 and 5. Results: The renal production of NH<sup>+</sup><sub>4</sub> was not significantly different in both acid-loaded groups, yet the rate of NH<sup>+</sup><sub>4</sub> excretion was significantly lower in the fasted dogs (8 vs. 21 mmol NH<sup>+</sup><sub>4</sub>/mmol creatinine). The urine pH was significantly higher (6.0 versus 5.5) while titratable acid and the urine flow rate were significantly lower in these fasted dogs. Despite nearly equal urine flow rates and Na<sup>+</sup> excretion rates after an infusion of saline, the fasted dogs failed to increase the rate of excretion of NH<sup>+</sup><sub>4</sub> to rates seen in the fed group. Conclusions: The lower rate of excretion of NH<sup>+</sup><sub>4</sub> in fasted, acidotic dogs appeared to be due to a lower distal H<sup>+</sup> secretion. This may help preserve lean body mass during fasting.

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          Prolonged total fasting: A feast for the integrative physiologist

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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            2002
            August 2002
            15 July 2002
            : 91
            : 4
            : 695-700
            Affiliations
            Renal Division, St. Michael’s Hospital, University of Toronto, Toronto, Ont., Canada
            Article
            65033 Nephron 2002;91:695–700
            10.1159/000065033
            12138275
            © 2002 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Tables: 4, References: 24, Pages: 6
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/65033
            Categories
            Original Paper

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