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      Autophagy and Inflammation.

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          Abstract

          The cellular degradative pathway of autophagy has a fundamental role in immunity. Here, we review the function of autophagy and autophagy proteins in inflammation. We discuss how the autophagy machinery controls the burden of infectious agents while simultaneously limiting inflammatory pathologies, which often involves processes that are distinct from conventional autophagy. Among the newly emerging processes we describe are LC3-associated phagocytosis and targeting by autophagy proteins, both of which require many of the same proteins that mediate conventional autophagy. We also discuss how autophagy contributes to differentiation of myeloid and lymphoid cell types, coordinates multicellular immunity, and facilitates memory responses. Together, these functions establish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases. Finally, we offer our perspective on current challenges and barriers to translation.

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          Author and article information

          Journal
          Annu. Rev. Immunol.
          Annual review of immunology
          Annual Reviews
          1545-3278
          0732-0582
          Apr 26 2018
          : 36
          Affiliations
          [1 ] Kimmel Center for Biology and Medicine at the Skirball Institute and.
          [2 ] Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA; email: Yu.Matsuzawa@nyumc.org , Ken.Cadwell@med.nyu.edu.
          [3 ] Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA; email: shwang@bsd.uchicago.edu.
          Article
          10.1146/annurev-immunol-042617-053253
          29144836
          46e7217f-c854-47dc-a6c6-e436efb5b8b3
          History

          autoimmune disease,autophagy,infectious disease,inflammatory bowel disease,inflammation

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